triethyl((2-iodobenzyl)oxy)silane | 1246008-13-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: triethyl((2-iodobenzyl)oxy)silane
• 英文别名: (2-iodobenzyloxy)triethylsilane；Triethyl-[(2-iodophenyl)methoxy]silane
• CAS: 1246008-13-8
• 化学式: C₁₃H₂₁IOSi
• 分子量: 348.299
• InChiKey: NKHIDVNQXCVXPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.81
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  triethyl((2-iodobenzyl)oxy)silane 在 copper diacetate 、 palladium diacetate 、 silver carbonate 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 18.0h， 生成
  参考文献：
  名称：

  Convergent One-Pot Oxidative [n+ 1] Approaches to Spiroacetal Synthesis

  摘要：

  Two one-pot oxidative annulative approaches to spiroacetal synthesis are described. One approach uses a Lewis acid mediated Ferrier reaction in the fragment-coupling stage followed by DDQ-promoted oxidative carbon-hydrogen bond cleavage and cyclization. An alternative approach employs a Heck reaction for fragment coupling followed by DDQ-mediated enone formation and cyclization. These strategies provide convergent routes to common subunits in natural products, medicinal agents, and chemical libraries under mild reaction conditions.

  DOI：

  10.1021/acs.orglett.5b01736
• 作为产物：
  描述：

  三乙基氯硅烷 、 2-碘苯甲酸 在 dimethyl sulfide borane 、 咪唑 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 triethyl((2-iodobenzyl)oxy)silane
  参考文献：
  名称：

  Convergent One-Pot Oxidative [n+ 1] Approaches to Spiroacetal Synthesis

  摘要：

  Two one-pot oxidative annulative approaches to spiroacetal synthesis are described. One approach uses a Lewis acid mediated Ferrier reaction in the fragment-coupling stage followed by DDQ-promoted oxidative carbon-hydrogen bond cleavage and cyclization. An alternative approach employs a Heck reaction for fragment coupling followed by DDQ-mediated enone formation and cyclization. These strategies provide convergent routes to common subunits in natural products, medicinal agents, and chemical libraries under mild reaction conditions.

  DOI：

  10.1021/acs.orglett.5b01736

文献信息

• Silylation of primary alcohols with recyclable ruthenium catalyst and hydrosilanes
  作者：Sungjin Kim、Min Serk Kwon、Jaiwook Park

  DOI：10.1016/j.tetlet.2010.06.119

  日期：2010.8

  The silylation of primary alcohols was achieved using hydrosilanes and a recyclable ruthenium catalyst without additives under mild conditions. Notably, this catalyst system is effective for the silylation of alcohols having haloaryl groups, which were intact during the silylation. (C) 2010 Elsevier Ltd. All rights reserved.