| 1201944-97-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• CAS: 1201944-97-9
• 化学式: C₁₈H₁₅Cl₂N₃O₂
• 分子量: 376.242
• InChiKey: WNGGXCOPRRDZOC-UHFFFAOYSA-N

物化性质

• 沸点：
  619.6±65.0 °C(predicted)
• 密度：
  1.49±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  在 肼 作用下， 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  Discovery of the first known small-molecule inhibitors of heme-regulated eukaryotic initiation factor 2α (HRI) kinase

  摘要：

  A series of indeno[1,2-c]pyrazoles were discovered to be the first known inhibitors of heme-regulated eukaryotic initiation factor 2 alpha (HRI) kinase. The synthesis, structure-activity relationship profile, and in-vitro pharmacological characterization of this inaugural series of HRI kinase inhibitors are detailed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.10.033