N1-(1-丙基-1H-苯并咪唑-2-基)-1,3-苯二甲酰胺 | 1111556-37-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 中文名称: N1-(1-丙基-1H-苯并咪唑-2-基)-1,3-苯二甲酰胺
• 英文名称: takinib
• 英文别名: N-(1-propyl-1H-benzo[d]imidazol-2-yl)isophthalamide；3-N-(1-propylbenzimidazol-2-yl)benzene-1,3-dicarboxamide
• CAS: 1111556-37-6
• 化学式: C₁₈H₁₈N₄O₂
• 分子量: 322.367
• InChiKey: UOZVVPXKJGOFIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  90
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-(氨基羰基)苯甲酸 、 1-丙基-1H-苯并咪唑-2-胺 在 N-甲基吗啉 、 1-羟基苯并三唑 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 4-二甲氨基吡啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.33h， 以80%的产率得到N1-(1-丙基-1H-苯并咪唑-2-基)-1,3-苯二甲酰胺
  参考文献：
  名称：

  NOVEL INHIBITORS OF TRANSFORMING GROWTH FACTOR KINASE AND METHODS OF USE THEREOF

  摘要：

  本发明提供了新型TAK1抑制剂以及使用这类化合物治疗各种疾病的方法。

  公开号：

  US20180105500A1

文献信息

• CELL AGGREGATION INCLUDING OLFACTORY NEURON OR PRECURSOR CELL THEREOF, AND METHOD FOR PRODUCING SAME
  申请人：SUMITOMO CHEMICAL COMPANY LIMITED

  公开号：EP3842527A1

  公开（公告）日：2021-06-30

  A method for producing a cell cluster including an olfactory receptor neuron or a precursor cell thereof, comprising the following steps (1) to (3): step (1) of suspension-culturing a pluripotent stem cell in the presence of a Wnt signaling pathway inhibitory substance to form a cell aggregate; step (2) of suspension-culturing the cell aggregate obtained in the step (1) in the presence of a BMP signaling pathway-activating substance; and step (3) of suspension-culturing the cell aggregate obtained in the step (2) to obtain the cell cluster, wherein step (3) comprises at least one step selected from the group consisting of: step (3a) of suspension-culturing in the presence of an FGF signaling pathway-activating substance; step (3b) of suspension-culturing in the presence of a BMP signaling pathway inhibitory substance; and step (3c) of culturing in the presence of an FGF signaling pathway-activating substance and a BMP signaling pathway inhibitory substance.

  一种生产包括嗅觉受体神经元或其前体细胞的细胞团的方法，包括以下步骤(1)至(3)：步骤(1)在Wnt信号通路抑制物质存在下悬浮培养多能干细胞以形成细胞聚集体；步骤(2)在BMP信号通路激活物质存在下悬浮培养步骤(1)中获得的细胞聚集体；以及步骤(3)悬浮培养步骤(2)中获得的细胞聚集体以获得细胞簇，其中步骤(3)包括至少一个选自由以下组成的组的步骤：在 FGF 信号通路激活物质存在下进行悬浮培养的步骤(3a)； 在 BMP 信号通路抑制物质存在下进行悬浮培养的步骤(3b)；以及 在 FGF 信号通路激活物质和 BMP 信号通路抑制物质存在下进行培养的步骤(3c)。
• Substituted benzimidazole and substituted benzothiazole inhibitors of transforming growth factor-β kinase and methods of use thereof
  申请人：Duke University

  公开号：US10207998B2

  公开（公告）日：2019-02-19

  The present invention provides novel inhibitors of TAK1 having formula (I) and methods of using such compounds to treat various diseases.

  本发明提供了具有式（I）的新型 TAK1 抑制剂以及使用此类化合物治疗各种疾病的方法。
• Substituted benzimidazoles as inhibitors of transforming growth factor-β kinase
  申请人：Duke University

  公开号：US10927083B2

  公开（公告）日：2021-02-23

  The present invention provides inhibitors of TAK1 having formula (II), affinity resins, and fluorescent dyes and methods of using such compounds to treat various diseases or in protein isolation or purification.

  本发明提供了具有式（II）的 TAK1 抑制剂、亲和树脂和荧光染料，以及使用此类化合物治疗各种疾病或分离或纯化蛋白质的方法。
• SUBSTITUTED BENZIMIDAZOLE AND BENZOTHIAZOLE INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA KINASE AND METHODS OF USE THEREOF
  申请人：Duke University

  公开号：US20190263759A1

  公开（公告）日：2019-08-29

  The present invention provides inhibitors of TAK1 having formula (II), affinity resins, and fluorescent dyes and methods of using such compounds to treat various diseases or in protein isolation or purification.
• SUBSTITUTED BENZIMIDAZOLES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA KINASE
  申请人：Duke University

  公开号：US20210188783A1

  公开（公告）日：2021-06-24

  The present invention provides inhibitors of TAK1 having formula (II), affinity resins, and fluorescent dyes and methods of using such compounds to treat various diseases or in protein isolation or purification.