SLSDSLSG-NH2 | 1588453-09-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: SLSDSLSG-NH2
• 英文别名: SLSDSLSG-NH₂
• CAS: 1588453-09-1
• 化学式: C₃₀H₅₃N₉O₁₄
• 分子量: 763.803
• InChiKey: BHZZNJCENOQCMA-BPSSIEEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -7.64
• 重原子数：
  53.0
• 可旋转键数：
  25.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  391.03
• 氢给体数：
  14.0
• 氢受体数：
  14.0

反应信息

• 作为产物：
  描述：

  Fmoc-甘氨酸 、 Fmoc-L-亮氨酸 、 alkaline earth salt of/the/ methylsulfuric acid 、 alkaline earth salt of/the/ methylsulfuric acid 在 Rink amide resin 、 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 N,N-二异丙基乙胺 、 哌啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.35h， 生成 SLSDSLSG-NH2
  参考文献：
  名称：

  Reversal of Aggregation Using β-Breaker Dipeptide Containing Peptides: Application to Aβ_(1–40) Self-Assembly and Its Inhibition

  摘要：

  Reversion of protein or peptide aggregation is a formidable task, important in various domains of research at the interface of chemistry, medicine, and nanoscience. A novel class of dipeptides, termed as fl-breaker dipeptides (BBDPs), is identified, which can be incorporated into the self-recognizing sequences to generate a novel class of conformational switch which forms fl-sheet at an initial stage and then converts in a controlled manner to random coil at specific conditions. Incorporation of BBDPs in a well designed amyloidogenic peptides generates a special class of fl-sheet breaker peptides those undergo a chemical change at physiological condition generating a breaker element in situ. These fl-breaker peptides are shown to first incorporate into the amyloid and then disrupt it. Such conformational switches may be used to study agrregation/disaggregation process and may find many biomedical applications relevant to aggregation related disorders. Such strategy for reversion of peptide aggregation using chemical tricks may find application in material chemistry as well.

  DOI：

  10.1021/cn500064z