n-hexyl α-hydroxymethylacrylate | 471266-76-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: n-hexyl α-hydroxymethylacrylate
• 英文别名: Hexyl 2-(hydroxymethyl)prop-2-enoate
• CAS: 471266-76-9
• 化学式: C₁₀H₁₈O₃
• 分子量: 186.251
• InChiKey: QLFOTAGUEIXGGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  n-hexyl α-hydroxymethylacrylate 在 硫酸 、 氢溴酸 作用下， 反应 0.25h， 生成 Hexyl 2-(bromomethyl)acrylate
  参考文献：
  名称：

  Synthesis, in vitro, and in vivo evaluation of novel functionalized quaternary ammonium curcuminoids as potential anti-cancer agents

  摘要：

  Novel functionalized quaternary ammonium curcuminoids have been synthesized from piperazinyl curcuminoids and Baylis-Hillman reaction derived allyl bromides. These molecules are found to be highly water soluble with increased cytotoxicity compared to native curcumin against three cancer cell lines MIAPaCa-2, MDA-MB-231, and 4T1. Preliminary in vivo toxicity evaluation of a representative curcuminoid 5a in healthy mice indicates that this molecule is well tolerated based on normal body weight gains compared to control group. Furthermore, the efficacy of 5a has been tested in a pancreatic cancer xenograft model of MIAPaCa-2 and has been found to exhibit good tumor growth inhibition as a single agent and also in combination with clinical pancreatic cancer drug gemcitabine. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2015.10.061
• 作为产物：
  描述：

  聚合甲醛 、 丙酯酸己酯 在 三乙烯二胺 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 12.0h， 生成 n-hexyl α-hydroxymethylacrylate
  参考文献：
  名称：

  Baylis–Hillman反应作为通过链式和阶梯式聚合合成各种功能化聚合物的多功能平台

  摘要：

  Baylis-Hillman反应是醛与活性烯烃之间的碳-碳键形成反应，用于制备适合链式和分步聚合的高密度官能化单体。通过使甲醛与各种丙烯酸烷基酯反应，合成了一系列烷基丙烯酸α-羟甲基酯单体。这些单体有效地进行了RAFT聚合，以提供具有良好控制的分子量和低多分散性的α-羟甲基取代的聚丙烯酸酯。所得的均聚物也是用于进一步的RAFT聚合的有效大链转移剂。Baylis-Hillman反应还用于合成烯烃官能化的二醇，然后逐步进行聚合反应以提供聚酯和聚（酯氨基甲酸酯）。此外，

  DOI：

  10.1021/ma4025416

文献信息

• ALKYL ALPHA-HYDROXYMETHYL ACRYLATES AS REACTIVE SURFACTANTS IN EMULSION POLYMERIZATION
  申请人：Joy Abraham

  公开号：US20160052858A1

  公开（公告）日：2016-02-25

  Polymers including α-hydroxymethylacrylate units and methods of preparing polymers from α-hydroxymethylacrylates are provided. Advantageously, α-hydroxymethylacrylates may be used in an emulsion polymerization and function as a polymerizable surfactant. The ability of the α-hydroxymethylacrylates to be used as a polymerizable surfactant allows for emulsion polymerization systems to be prepared without other surfactants.

  提供了包括α-羟甲基丙烯酸酯单元的聚合物以及从α-羟甲基丙烯酸酯制备聚合物的方法。优点是，α-羟甲基丙烯酸酯可以在乳液聚合中使用，并作为可聚合的表面活性剂。α-羟甲基丙烯酸酯作为可聚合的表面活性剂的能力使得可以制备不需要其他表面活性剂的乳液聚合体系。
• Acrylic ester derivative and producing process of the same and acrylic-ester-based polymer
  申请人：NIPPON SHOKUBAI CO., LTD.

  公开号：EP0755951A2

  公开（公告）日：1997-01-29

  An acrylic ester derivative expressed by Formula (1) below is produced by reacting an acrylic ester expressed by Formula (2) below with a saccharide containing a hemiacetal hydroxyl group expressed by Formula (3) below and/or an alkylglycoside expressed by Formula (4) below: where R1 represents a hydrogen atom or organic residue, R2 represents a hydrogen atom, counter ion, or organic residue, and G represents a saccharic residue; where R1 represents a hydrogen atom or organic residue and R2 represents a hydrogen atom, a counter ion, or organic residue;         G-H     (3) where G represents a saccharic residue; and         G-R3     (4) where G represents a saccharic residue and R3 represents an organic residue. An acrylic-ester-based polymer is produced by letting a monomeric component containing such an acrylic ester derivative undergo polymerization. The resulting acrylic-ester-based polymer renders excellent hydrophilic property, biodegrability, and bioadaptability, and therefore, can be preferably used as a surface finishing agent, a medical material, a water absorptive resin, a surfactant, etc.

  由下式（1）表示的丙烯酸酯衍生物是通过由下式（2）表示的丙烯酸酯与含有由下式（3）表示的半缩醛羟基的糖和/或由下式（4）表示的烷基糖苷反应制得的： 其中 R1 代表氢原子或有机残基，R2 代表氢原子、反离子或有机残基，G 代表糖残基； 其中 R1 代表氢原子或有机残基，R2 代表氢原子、对位离子或有机残基； G-H (3) 其中 G 代表糖残基；以及 G-R3 (4) 其中 G 代表糖残基，R3 代表有机残基。让含有这种丙烯酸酯衍生物的单体成分发生聚合反应，可生产出丙烯酸酯基聚合物。由此产生的丙烯酸酯基聚合物具有优异的亲水性、生物可降解性和生物适应性，因此可优先用作表面处理剂、医用材料、吸水性树脂、表面活性剂等。
• Ink-jet printing methods and systems providing dry rub resistance
  申请人：Hewlett-Packard Development Company, L.P.

  公开号：EP1462255A1

  公开（公告）日：2004-09-29

  Systems and methods for providing dry rub resistance and reduced dry rub transfer are provided. Specifically, a system for printing durable ink-jet images having good dry rub resistance can comprise a substrate, a first ink-jet pen, and a slip component. The first ink-jet pen can contain an ink-jet ink configured for being jetted onto the substrate and can comprise a first liquid vehicle, and an effective amount of a pigment colorant. The slip component can be configured for being coated over the ink-jet ink once jetted onto the substrate. In one embodiment, the ink-jet ink can further comprise an effective amount of a latex. In another embodiment, a fixer composition can be used for overprinting or underprinting with respect to the ink-jet ink. A method of the present invention can utilize the above system.

  本文提供了提供抗干摩擦性和减少干摩擦转移的系统和方法。具体来说，用于打印具有良好耐干摩擦性的耐用喷墨图像的系统可包括基底、第一喷墨笔和滑移组件。第一喷墨笔可以包含喷墨墨水，配置为喷射到基底上，可以包含第一液体载体和有效量的颜料着色剂。一旦喷墨墨水喷射到基底上，滑移组件可配置为涂覆在喷墨墨水上。在一个实施方案中，喷墨墨水可以进一步包含有效量的胶乳。在另一个实施方案中，定影剂组合物可用于喷墨墨水的叠印或欠印。本发明的方法可以利用上述系统。
• Ink-jet imaging on offset media
  申请人：Hewlett-Packard Development Company, L.P.

  公开号：EP1577354A2

  公开（公告）日：2005-09-21

  The present invention is draw to the use of post calendaring of ink-jet produced images on offset media to improve smudge resistance and image quality. More specifically, a system for printing durable ink-jet ink images can comprise offset media; an ink-jet ink; and a calendaring device. The ink-jet ink can include a pigment colorant, and can be configured to be printed on the offset media. The calendaring device can be configured for applying pressure to offset media once the ink-jet ink is printed thereon. A method is also provide that comprises steps of ink-jetting an ink-jet ink onto offset media to form a printed image, wherein the ink-jet ink includes a pigment colorant; and applying pressure to the printed image such that a physical property of the printed image is altered by the pressure.

  本发明涉及在胶印介质上对喷墨图像进行后压光，以提高抗污能力和图像质量。更具体地说，打印耐用喷墨图像的系统可包括胶印介质、喷墨墨水和压光设备。喷墨墨水可包括颜料着色剂，并可配置为在胶印介质上打印。压光装置可配置为在胶印介质上打印喷墨墨水后对胶印介质施加压力。还提供了一种方法，包括以下步骤：将喷墨墨水喷印到胶印介质上以形成印刷图像，其中喷墨墨水包括颜料着色剂；以及对印刷图像施加压力，使印刷图像的物理特性因压力而改变。
• Alkyl alpha-hydroxymethyl acrylates as reactive surfactants in emulsion polymerization
  申请人：Joy Abraham

  公开号：US10118887B2

  公开（公告）日：2018-11-06

  Polymers including α-hydroxymethylacrylate units and methods of preparing polymers from α-hydroxymethylacrylates are provided. Advantageously, α-hydroxymethylacrylates may be used in an emulsion polymerization and function as a polymerizable surfactant. The ability of the α-hydroxymethylacrylates to be used as a polymerizable surfactant allows for emulsion polymerization systems to be prepared without other surfactants.

  提供了包括 α-羟甲基丙烯酸酯单元的聚合物和用α-羟甲基丙烯酸酯制备聚合物的方法。有利的是，α-羟甲基丙烯酸酯可用于乳液聚合，并起到可聚合表面活性剂的作用。由于α-羟甲基丙烯酸酯可用作可聚合表面活性剂，因此无需其他表面活性剂即可制备乳液聚合体系。