(Z)-2-((4-chlorophenyl)amino)-2-oxo-N-phenylethan-1-imine oxide | 1447755-49-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (Z)-2-((4-chlorophenyl)amino)-2-oxo-N-phenylethan-1-imine oxide
• CAS: 1447755-49-8
• 化学式: C₁₄H₁₁ClN₂O₂
• 分子量: 274.707
• InChiKey: OUNITWJBZHETJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.19
• 重原子数：
  19.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  55.17
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (Z)-2-((4-chlorophenyl)amino)-2-oxo-N-phenylethan-1-imine oxide 在 四丁基氟化铵 作用下， 以 四氢呋喃 、 氯苯 、 甲苯 为溶剂， 反应 4.67h， 生成 1-(4-chlorophenyl)-5-hydroxy-3-(phenylamino)-1,5-dihydro-2H-pyrrol-2-one
  参考文献：
  名称：

  A Highly Efficient and Stereoselective Cycloaddition of Nitrones to N-Vinylpyrroles

  摘要：

  1,3-Dipolar cycloadditions of a number of C-aryl, C-carbamoyl-, and C,C-bis(methoxycarbonyl)nitrones and substituted N-vinylpyrroles proceed with high efficiency and regioselectivity with the formation of only one isomeric substituted 5-(1H-pyrrol-1-yl)isoxazolidine cycloadduct.

  DOI：

  10.1055/s-0033-1340479

文献信息

• Regioselective cycloaddition of C,N-diarylnitrones to arylallenes and of N-aryl-C-carbamoylnitrones to methyl buta-2,3-dienoate
  作者：A. P. Molchanov、Yu. V. Malinina、R. R. Kostikov、A. V. Stepakov

  DOI：10.1134/s1070428015030136

  日期：2015.3

  Cycloadditions of C,N-diarylnitrones to non-activated arylallenes and of N-aryl-C-carbamoylnitrones to methyl buta-2,3-dienoate regioselectively afforded mixtures of diastereoisomeric substituted 4-methylideneisoxazolidines.
• Regio- and stereoselective cycloaddition of C-Carbamoylnitrones to 1-benzylidene-3,3-dichloro-2,2-dimethylcyclopropane
  作者：A. P. Molchanov、T. Q. Tran

  DOI：10.1007/s10593-013-1271-8

  日期：2013.6

  C-Carbamoylnitrones add regio- and stereoselectively to 1-benzylidene-3,3-dichloro-2,2-dimethyl-cyclopropane with the formation of one diastereomer of 4-spirocyclopropaneisoxazolidine.
• Regioselective cycloaddition of C-carbamoylnitrones to methyl (E)-2-(2-phenylcyclopropylidene)acetate and methyl (E)-2-methylidene-3-phenylcyclopropane-1-carboxylate
  作者：A. P. Molchanov、T. Q. Tran、A. V. Stepakov、G. L. Starova、R. R. Kostikov

  DOI：10.1134/s1070428014010151

  日期：2014.1

  N-Aryl-C-(arylcarbamoyl)nitrones regioselectively add to methyl 2-(2-phenylcyclopropylidene)-acetate and methyl 2-methylidene-3-phenylcyclopropanecarboxylate to give in each case two diastereoisomeric 5-oxa-6-azaspiro[2.4]heptane-4-carboxylates.