N-(6-chloro-3-methylimidazo[1,2-a]pyridin-2-yl)-N-[[3-fluoro-4-(trifluoromethyl)phenyl]methyl]-4-pyrazol-1-ylbenzenesulfonamide | 1381785-14-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(6-chloro-3-methylimidazo[1,2-a]pyridin-2-yl)-N-[[3-fluoro-4-(trifluoromethyl)phenyl]methyl]-4-pyrazol-1-ylbenzenesulfonamide
• CAS: 1381785-14-3
• 化学式: C₂₅H₁₈ClF₄N₅O₂S
• 分子量: 563.963
• InChiKey: OMGRDHUWVXCZEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  38
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  80.9
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• IMIDAZO[1,2-a]PYRIDINE SULFONAMIDES AS TRPM8 MODULATORS
  申请人：Macielag Mark J.

  公开号：US20120149699A1

  公开（公告）日：2012-06-14

  Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein Y, R 1 , R 2 , and are defined herein.

  揭示了用于治疗各种疾病、综合征、状况和障碍的化合物、组合物和方法，包括疼痛。这些化合物由以下的化学式I代表：其中Y、R1、R2和在此有定义。
• [EN] IMIDAZO [1, 2-A] PYRIDINE SULFONAMIDES AS TRPM8 MODULATORS<br/>[FR] IMIDAZO[1,2-A]PYRIDINESULFONAMIDES EN TANT QUE MODULATEURS DE TRPM8
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2012078994A1

  公开（公告）日：2012-06-14

  Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows:wherein Y, R1, R2, and are defined herein.