tert-butyl 7-(4-((5-fluoropyridin-2-yl)methoxy)-2-oxopyridin-1(2H)-yl)-3,4-dihydropyrido[4',3':4,5]imidazo[1,2-a]pyridine-2 (1H)-carboxylate | 1382805-24-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: tert-butyl 7-(4-((5-fluoropyridin-2-yl)methoxy)-2-oxopyridin-1(2H)-yl)-3,4-dihydropyrido[4',3':4,5]imidazo[1,2-a]pyridine-2 (1H)-carboxylate
• 英文别名: Tert-butyl 11-[4-[(5-fluoropyridin-2-yl)methoxy]-2-oxopyridin-1-yl]-1,4,8-triazatricyclo[7.4.0.02,7]trideca-2(7),8,10,12-tetraene-4-carboxylate
• CAS: 1382805-24-4
• 化学式: C₂₆H₂₆FN₅O₄
• 分子量: 491.522
• InChiKey: NAUOLFUJQSQECF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  89.3
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• TETRAHYDRO-AZACARBOLINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USES THEREOF
  申请人：SURMAN Matthew D.

  公开号：US20120157460A1

  公开（公告）日：2012-06-21

  The present invention relates to tetrahydro-azacarboline derivatives of formula (I): having the substituents as described herein which are melanin-concentrating hormone (MCH-1) receptor antagonists. The present invention also relates to pharmaceutical compositions including these compounds, and methods of preparation and use thereof.

  本发明涉及式(I)的四氢-吖啶咔啉衍生物，其具有如本文所述的取代基，这些取代基是黑素浓缩激素（MCH-1）受体拮抗剂。本发明还涉及包括这些化合物的药物组合物，以及其制备和使用方法。
• US8993765B2
  申请人：——

  公开号：US8993765B2

  公开（公告）日：2015-03-31
• [EN] TETRAHYDRO-AZACARBOLINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USES THEREOF<br/>[FR] ANTAGONISTES DE LA MCH-1 À BASE DE TÉTRAHYDRO-AZACARBOLINE, LEURS PROCÉDÉS DE FABRICATION ET LEURS UTILISATIONS
  申请人：ALBANY MOLECULAR RES INC

  公开号：WO2012088124A2

  公开（公告）日：2012-06-28

  The present invention relates to tetrahydro-azacarboline derivatives of formula (I) having the substituents as described herein which are melanin-concentrating hormone (MCH-1) receptor antagonists. The present invention also relates to pharmaceutical compositions including these compounds, and methods of preparation and use thereof.