1,3-diphenylprop-2-yn-1-one-2-13C | 1202553-62-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1,3-diphenylprop-2-yn-1-one-2-13C
• CAS: 1202553-62-5
• 化学式: C₁₅H₁₀O
• 分子量: 207.233
• InChiKey: YECVQOULKHBGEN-HNHCFKFXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.92
• 重原子数：
  16.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.07
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  (R)-2-azido-3-phenylpropan-1-ol 、 1,3-diphenylprop-2-yn-1-one-2-13C 在 三丁基膦 作用下， 以 甲苯 为溶剂， 反应 14.0h， 生成 C₂₃⁽¹³⁾CH₂₁NO
  参考文献：
  名称：

  A Phosphine-Mediated Construction of 1,4-Oxazepines and 1,3-Oxazines

  摘要：

  A simple and efficient method for constructing 1,4-oxazepines and 1,3-oxazines was developed with use of a phosphine-mediated tandem reaction of ynones with 2-azido alcohols. The method offers a promising route to synthetically useful as well as biologically active heterocycles under mild conditions and may be exploited for the preparation of interesting chiral ligands.

  DOI：

  10.1021/ol9024309
• 作为产物：
  描述：

  苯乙炔-2-13C 、 苯甲酰氯 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 作用下， 生成 1,3-diphenylprop-2-yn-1-one-2-13C
  参考文献：
  名称：

  A Phosphine-Mediated Construction of 1,4-Oxazepines and 1,3-Oxazines

  摘要：

  A simple and efficient method for constructing 1,4-oxazepines and 1,3-oxazines was developed with use of a phosphine-mediated tandem reaction of ynones with 2-azido alcohols. The method offers a promising route to synthetically useful as well as biologically active heterocycles under mild conditions and may be exploited for the preparation of interesting chiral ligands.

  DOI：

  10.1021/ol9024309

文献信息

• <scp>Palladium‐Catalyzed</scp> Oxidative C≡C Triple Bond Cleavage of <scp>2‐Alkynyl</scp> Carbonyl Compounds Toward 1, <scp>2‐Dicarbonyl</scp> Compounds ^†
  作者：Ming‐Bo Zhou、Mu‐Jia Luo、Ming Hu、Jin‐Heng Li

  DOI：10.1002/cjoc.202000040

  日期：2020.6

  palladium‐catalyzed oxidative strategy for the cleavage of the C≡C triple bond is presented. By employing PdCl2, CuBr2, TEMPO and air as the catalytic system and H2O as the carbonyl oxygen atom source, a wide range of 2‐alkynyl carbonyl compounds, including 1,3‐disubstituted prop‐2‐yn‐1‐ones, propiolamides and propiolates, lost an alkynyl carbon to access various 1,2‐dicarbonyl compounds, e.g., 1,2‐diones

  提出了一种新的，一般的钯催化的氧化C≡C三键的氧化策略。通过使用PdCl 2，CuBr 2，TEMPO和空气作为催化体系，并使用H 2 O作为羰基氧原子源，可以使用多种2-炔基羰基化合物，包括1,3-二取代的prop-2-yn-1炔烃。丙酰胺和丙酸酯类化合物通过Wacker氧化，分子内环化和C-C键失去炔基碳而无法获得各种1,2-二羰基化合物，例如1,2-二酮，2-酮酰胺和2-酮酯卵裂级联