1-(2,5-dimethoxy-4-nitro-phenyl)-4-methyl-piperazine | 5521-26-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(2,5-dimethoxy-4-nitro-phenyl)-4-methyl-piperazine
• 英文别名: Piperazine,1-(2,5-dimethoxy-4-nitrophenyl)-4-methyl-；1-(2,5-dimethoxy-4-nitrophenyl)-4-methylpiperazine
• CAS: 5521-26-6
• 化学式: C₁₃H₁₉N₃O₄
• 分子量: 281.312
• InChiKey: PUNXUNOLLYACNX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  70.8
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• 2, 4-Pyrimidinediamines Useful In The Treatment Of Neoplastic Diseases, Inflammatory And Immune System Disorders
  申请人：Garcia-Echeverria Carlos

  公开号：US20080132504A1

  公开（公告）日：2008-06-05

  Novel pyrimidine derivatives of formula I to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them

  式I的新型嘧啶衍生物及其制备方法，它们的药用价值以及包含它们的药物组合物。
• PYRIMIDINE DERIVATIVES
  申请人：Garcia-Echeverria Carlos

  公开号：US20110201606A1

  公开（公告）日：2011-08-18

  Novel pyrimidine derivatives of formula I to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them

  式I的新型嘧啶衍生物及其制备方法，其用作药物和含有它们的药物组合物。
• 2,4-PYRIMIDINEDIAMINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS
  申请人：Garcia-Echeverria Carlos

  公开号：US20110098280A1

  公开（公告）日：2011-04-28

  Novel pyrimidine derivatives of formula I to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

  I类新型嘧啶衍生物的制备方法，以及它们作为药物和药物组合物的用途。
• 2,4-di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders.
  申请人：Novartis AG

  公开号：EP2275413A1

  公开（公告）日：2011-01-19

  Novel pyrimidine derivatives of formula (I), to processes for their production, their use as IGF-1R and ALK-inhibitors in the treatment of neoplastic diseases, inflammatory and immune system disorders and to pharmaceutical compositions comprising them.

  式（I）的新型嘧啶衍生物，其生产工艺，在治疗肿瘤性疾病、炎症和免疫系统疾病中作为 IGF-1R 和 ALK 抑制剂的用途，以及包含它们的药物组合物。
• 2,4-Di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders
  申请人：Novartis AG

  公开号：EP2287156A1

  公开（公告）日：2011-02-23

  Novel pyrimidine derivatives of formula (I) and their use for the manufacture of a medicament for the treatment or prevention of a disease which responds to inhibition of FAK and/or ALK and/or ZAP-70 and/or IGF-IR. in which: n' is selected from 1,2 and 3; R'1is selected from phenyl, pyridinyl, pyrazolyl and pyrimidinyl; and R'2 and R'3 are as described herein.

  式(I)的新型嘧啶衍生物及其用于制造治疗或预防对抑制FAK和/或ALK和/或ZAP-70和/或IGF-IR有反应的疾病的药物。 其中：n'选自 1、2 和 3； R'1 选自苯基、吡啶基、吡唑基和嘧啶基； 以及 R'2 和 R'3 如本文所述。