3-苄基-6-（4-羟基苄基）-2,5-哌嗪二酮 | 5147-17-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 3-苄基-6-（4-羟基苄基）-2,5-哌嗪二酮
• 英文名称: cyclo(Phe-Tyr)
• 英文别名: Cyclo(Tyr-Phe)；3-benzyl-6-[(4-hydroxyphenyl)methyl]piperazine-2,5-dione
• CAS: 5147-17-1
• 化学式: C₁₈H₁₈N₂O₃
• 分子量: 310.353
• InChiKey: GRWVBLRIPRGGPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• GADD45BETA TARGETING AGENTS
  申请人：Franzoso Guido

  公开号：US20120277164A1

  公开（公告）日：2012-11-01

  Compounds based around tetrapeptide, tripeptide and dipeptide moeties and corresponding peptiod moeties. Related methods and pharmaceutical compositions for use in treatment of cancer, inflammatory diseases, and other disorders.

  基于四肽、三肽和二肽基团以及相应的肽基团的化合物。用于治疗癌症、炎症性疾病和其他疾病的相关方法和药物组合。
• Method of diagnosis and prognosis
  申请人：Franzoso Guido

  公开号：US10697019B2

  公开（公告）日：2020-06-30

  A method of measuring Gadd45β expression comprising the step of measuring Gadd45β expression levels in a sample of cells, for example CD 138 expressing cells, obtained from a subject known to have or suspected of having a haematological malignancy. Expression levels may be used in diagnosis, for example of multiple myeloma, in providing a prognosis, for example in a patient having multiple myeloma or in guiding selection of an appropriate treatment agent, especially a treatment agent comprising Gadd45β and or MKK7 inhibitors. Also datasets comprising measured expression levels from multiple subjects.

  一种测量 Gadd45β 表达的方法，包括测量从已知患有或怀疑患有血液恶性肿瘤的受试者处获得的细胞样本（例如表达 CD 138 的细胞）中的 Gadd45β 表达水平。表达水平可用于诊断（例如多发性骨髓瘤）、提供预后（例如多发性骨髓瘤患者的预后）或指导选择适当的治疗药物，特别是包括 Gadd45β 和或 MKK7 抑制剂的治疗药物。此外，数据集还包括多个受试者的测量表达水平。
• Gel-like shaped body for fragrancing textiles during the washing process
  申请人：Henkel AG & Co. KGaA

  公开号：US11180717B2

  公开（公告）日：2021-11-23

  The present invention is in the field of washing and cleaning agents and relates to a fragranced shaped body, including a composition obtained by bringing the following components into contact: (a) at least one gelling agent having a molar mass of <2000 g/mol and (b) at least one fragrance. The invention also relates to a washing or cleaning agent, including the fragranced shaped body according to the invention, a method for producing the fragranced shaped body according to the invention and the use of the fragranced shaped body according to the invention for fragrancing surfaces.

  本发明属于洗涤剂和清洁剂领域，涉及一种香味定型体，包括一种通过使以下成分接触而获得的组合物：(a) 至少一种摩尔质量小于 2000 g/mol 的胶凝剂和 (b) 至少一种香料。本发明还涉及一种洗涤剂或清洁剂，包括根据本发明制成的有香味的异型体，一种生产根据本发明制成的有香味的异型体的方法，以及根据本发明制成的有香味的异型体用于表面加香的用途。
• EP3749738A1
  申请人：——

  公开号：EP3749738A1

  公开（公告）日：2020-12-16
• EP3749739A1
  申请人：——

  公开号：EP3749739A1

  公开（公告）日：2020-12-16