tert-butyl N-[2-(2-amino-5-chloro-4-methylphenoxy)ethyl]-N-methylcarbamate | 862874-05-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: tert-butyl N-[2-(2-amino-5-chloro-4-methylphenoxy)ethyl]-N-methylcarbamate
• CAS: 862874-05-3
• 化学式: C₁₅H₂₃ClN₂O₃
• 分子量: 314.812
• InChiKey: YFWQKZFATDSUAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  64.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  tert-butyl N-[2-(5-chloro-4-methyl-2-nitrophenoxy)ethyl]-N-methylcarbamate 在 镍 氢气 作用下， 以 四氢呋喃 为溶剂， 以96%的产率得到tert-butyl N-[2-(2-amino-5-chloro-4-methylphenoxy)ethyl]-N-methylcarbamate
  参考文献：
  名称：

  [EN] SUBSTITUTED BISARYLUREA DERIVATIVES AS KINASE INHIBITORS
  [FR] DERIVES DE BISARYLUREE

  摘要：

  公开号：

  WO2005075425A3

文献信息

• [EN] BENZIMIDAZOLYL DERIVATIVES AS KINASE INHIBITORS<br/>[FR] DERIVES DE BENZIMIDAZOLYLE
  申请人：MERCK PATENT GMBH

  公开号：WO2005082862A3

  公开（公告）日：2005-12-01
• Bisarylurea derivatives
  申请人：Buchstaller Hans-Peter

  公开号：US20070161677A1

  公开（公告）日：2007-07-12

  The present invention relates to bisarylurea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
• Benzimidazolyl derivatives
  申请人：Buchstaller Hans-Peter

  公开号：US20070191444A1

  公开（公告）日：2007-08-16

  The present invention relates to benzimidazolyl derivatives of formula (I), with the definition of R 8 , p , Ar 1 , E, D, R 9 , q and R 10 according to claim 1 , the use of the compounds of formula (I) as inhibitors of one or more kinases, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
• Semicarbazide derivatives as kinase inhibitors
  申请人：Buchstaller Hans-Peter

  公开号：US20090253688A1

  公开（公告）日：2009-10-08

  The present invention relates to semicarbazide derivatives of formula I, the use of the compounds of formula I as inhibitors of one or more kinases, the use of the compounds of formula I for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
• [EN] SUBSTITUTED BISARYLUREA DERIVATIVES AS KINASE INHIBITORS<br/>[FR] DERIVES DE BISARYLUREE
  申请人：MERCK PATENT GMBH

  公开号：WO2005075425A3

  公开（公告）日：2006-12-14