(2R,4'S,4"S,5'R)-(4-methoxybenzenesulfonylamino)-(2',2',2",2"-tetramethyl-[4',4"]bis[[1,3]dioxolanyl]-5'-yl)-acetic acid methyl ester | 607707-72-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R,4'S,4"S,5'R)-(4-methoxybenzenesulfonylamino)-(2',2',2",2"-tetramethyl-[4',4"]bis[[1,3]dioxolanyl]-5'-yl)-acetic acid methyl ester
• 英文别名: methyl (2R)-2-[(4R,5S)-5-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethyl-1,3-dioxolan-4-yl]-2-[(4-methoxyphenyl)sulfonylamino]acetate
• CAS: 607707-72-2
• 化学式: C₂₀H₂₉NO₉S
• 分子量: 459.518
• InChiKey: BQJRZSSVQSXMSV-YLFCFFPRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  127
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  (2R,4'S,4"S,5'R)-(4-methoxybenzenesulfonylamino)-(2',2',2",2"-tetramethyl-[4',4"]bis[[1,3]dioxolanyl]-5'-yl)-acetic acid methyl ester 在 a cation exchange resin (Muromac) 作用下， 以 甲醇 、 水 为溶剂， 反应 72.0h， 生成 (1"S,2R,4'R,5'R)-[5'-(1",2"-dihydroxy-ethyl)-2',2'-dimethyl-[1,3]dioxolan-4'-yl]-(4-methoxybenzenesulfonylamino)-acetic acid methyl ester
  参考文献：
  名称：

  EP1516872

  摘要：

  公开号：
• 作为产物：
  描述：

  Methyl 2-azido-2-deoxy-3,4:5,6-O-diisopropylidene-L-idonate 在 palladium on activated charcoal 4-二甲氨基吡啶 、 氢气 作用下， 以 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 生成 (2R,4'S,4"S,5'R)-(4-methoxybenzenesulfonylamino)-(2',2',2",2"-tetramethyl-[4',4"]bis[[1,3]dioxolanyl]-5'-yl)-acetic acid methyl ester
  参考文献：
  名称：

  Structure–activity relationships of azasugar-based MMP/ADAM inhibitors

  摘要：

  In order to investigate structure-activity relationships of azasugar series toward metalloprotemases, we synthesized and evaluated several azasugar-based compounds. As a result, it was found that 4-phenoxybenzene derivative 3 having 2R,3R,4R,5S-configurations exhibited most potent inhibitory activities against matrix metalloproteinase-1, -3 and -9 and TACE. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00530-4

文献信息

• EP1516872
  申请人：——

  公开号：——

  公开（公告）日：——
• US7223779B2
  申请人：——

  公开号：US7223779B2

  公开（公告）日：2007-05-29
• Structure–activity relationships of azasugar-based MMP/ADAM inhibitors
  作者：Hideki Moriyama、Takahiro Tsukida、Yoshimasa Inoue、Hirosato Kondo、Kohichiro Yoshino、Shin-Ichiro Nishimura

  DOI：10.1016/s0960-894x(03)00530-4

  日期：2003.8

  In order to investigate structure-activity relationships of azasugar series toward metalloprotemases, we synthesized and evaluated several azasugar-based compounds. As a result, it was found that 4-phenoxybenzene derivative 3 having 2R,3R,4R,5S-configurations exhibited most potent inhibitory activities against matrix metalloproteinase-1, -3 and -9 and TACE. (C) 2003 Elsevier Ltd. All rights reserved.