(5α,8α,10α)-6,7-didehydro-4,5-epoxy-17-methylmorphinan-3,8,10-triol | 1188377-79-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: (5α,8α,10α)-6,7-didehydro-4,5-epoxy-17-methylmorphinan-3,8,10-triol
• 英文别名: 10α-hydroxy-β-isomorphine；10alpha-Hydroxy-beta-isomorphine；(4S,4aR,5R,7aS,12bS,13S)-3-methyl-2,4,4a,5,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-5,9,13-triol
• CAS: 1188377-79-8
• 化学式: C₁₇H₁₉NO₄
• 分子量: 301.342
• InChiKey: NRTVZEUDAAWSHI-LHSDCZHYSA-N

物化性质

• 熔点：
  235 °C (decomp)(Solv: methanol (67-56-1); water (7732-18-5))
• 沸点：
  541.9±50.0 °C(Predicted)
• 密度：
  1.54±0.1 g/cm3(Predicted)

反应信息

• 作为产物：
  描述：

  10α-hydroxycodeine-6,10-diacetate 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 以50%的产率得到(5α,8α,10α)-6,7-didehydro-4,5-epoxy-17-methylmorphinan-3,8,10-triol
  参考文献：
  名称：

  10α-Hydroxy-β-isomorphine, a by-product of the synthesis of 10α-hydroxymorphine

  摘要：

  A new compound was isolated from the reaction mixture after O-demethylation of 6-O-acetyl-10 alpha-acetoxycodeine with boron tribromide. The structure of this compound, 10 alpha-hydroxy-beta-isomorphine, was elucidated by spectral data, and its spatial arrangement was deduced from an NOE experiment. Capillary zone electrophoresis was used for separation of morphine and its 10-hydroxy analogues.

  DOI：

  10.1007/s00706-008-0077-3