N-(sec-butyl)-7-(2-chloro-4-methoxyphenyl)-2,6-dimethylpyrazolo[1,5-a]pyridin-3-amine | 605672-62-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(sec-butyl)-7-(2-chloro-4-methoxyphenyl)-2,6-dimethylpyrazolo[1,5-a]pyridin-3-amine
• 英文别名: N-butan-2-yl-7-(2-chloro-4-methoxyphenyl)-2,6-dimethylpyrazolo[1,5-a]pyridin-3-amine
• CAS: 605672-62-6
• 化学式: C₂₀H₂₄ClN₃O
• 分子量: 357.883
• InChiKey: VNIHYOJPZWDFTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  38.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Novel pyrazolo[1,5-a]pyridine derivatives and their use as neurotransmitter modulators
  申请人：——

  公开号：US20040002511A1

  公开（公告）日：2004-01-01

  The present invention relates to novel pyrazolo[1,5-a]pyridine derivatives of general formula I: 1 that bind with high affifnity to CRF 1 receptors, including human CRF 1 receptors. This invention also relates to methods of using the compounds of the invention to treat a disorder or condition, the treatment of which can be effected or facilitated by antagonizing a CRF receptor, such as CNS disorders or diseases, particularly anxiety disorders, and depression and stress related disorders.

  本发明涉及一种新型的嘧啶并[1,5-a]吡啶衍生物，其一般化学式为I:1，能够与CRF1受体高亲和力结合，包括人类CRF1受体。本发明还涉及使用本发明的化合物治疗某种疾病或症状的方法，该疾病或症状的治疗可以通过拮抗CRF受体来实现或促进，例如中枢神经系统疾病或疾病，尤其是焦虑症、抑郁症和与压力相关的疾病。
• 3-pyridyl or 4-isoquinolinyl thiazoles as c17, 20 lyase inhibitors
  申请人：——

  公开号：US20040267017A1

  公开（公告）日：2004-12-30

  The invention provides novel thiazoles bearing 3-pyridyl or 4-isoquinilinyl substituents, and pharmaceutical compositions thereof. The invention also provides methods of using compounds of the invention and pharmaceutical compositions thereof as inhibitors of lyases, e.g., the 17a-hydroxylase-C17,20 enzyme. The invention further provides methods for treating cancer in a subject, comprising administering to the subject a compound of the invention or a pharmaceutical composition thereof. The cancer can be, e.g., prostate cancer or breast cancer.

  本发明提供了一种带有3-吡啶基或4-异喹啉基取代基的新型噻唑，并提供了其制药组合物。本发明还提供了使用本发明化合物和制药组合物作为裂解酶抑制剂（例如17a-羟基酶-C17,20酶）的方法。本发明还提供了治疗患者癌症的方法，包括向患者投药本发明化合物或制药组合物。癌症可以是前列腺癌或乳腺癌等。
• 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS
  申请人：Bayer Pharmaceuticals Corporation

  公开号：EP1432706A2

  公开（公告）日：2004-06-30
• PYRAZOLO(1,5-A)PYRIDINE DERIVATIVES AS NEUROTRANSMITTER MODULATORS
  申请人：Pharmacia & Upjohn Company LLC

  公开号：EP1485384A1

  公开（公告）日：2004-12-15
• US7151109B2
  申请人：——

  公开号：US7151109B2

  公开（公告）日：2006-12-19