| 1130916-25-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 1130916-25-4
• 化学式: C₂₇H₂₈N₂O₅
• 分子量: 460.53
• InChiKey: GEUHXOOZBATCPO-DEOSSOPVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.12
• 重原子数：
  34.0
• 可旋转键数：
  11.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  93.73
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  dibenzyl (2S)-5-oxotetrahydro-1H-pyrrole-1,2-dicarboxylate 、 苄胺 以 二氯甲烷 为溶剂， 反应 96.0h， 生成
  参考文献：
  名称：

  Regioselective synthesis of folic acid conjugates from diether-type archaeal lipid analogues

  摘要：

  A regioselective access to both alpha- and gamma-folic acid conjugates derived from archaeal lipid analogues is described. The synthetic approach is based on conveniently protected glutamates that led first to alpha- and gamma-glutamate derivatives. The final reconstruction of the folic acid moiety was achieved through the reaction of a protected/activated pteroate followed by a simple deprotection step. These alpha- and gamma-folic acid conjugates Would permit to establish the importance of a regiocontrolled introduction of folic acid on the folic acid/folate receptor interaction in the case of a targeted drug/gene delivery. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.12.013