methyl 2(S)-ethoxy-3-{4-[2-(1-methyl-3-pentylureido)thiazol-5-yl]phenyl}propanoate | 817618-18-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: methyl 2(S)-ethoxy-3-{4-[2-(1-methyl-3-pentylureido)thiazol-5-yl]phenyl}propanoate
• 英文别名: methyl (2S)-2-ethoxy-3-[4-[2-[methyl(pentylcarbamoyl)amino]-1,3-thiazol-5-yl]phenyl]propanoate
• CAS: 817618-18-1
• 化学式: C₂₂H₃₁N₃O₄S
• 分子量: 433.572
• InChiKey: DVCBCILNULMETR-SFHVURJKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  30
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  109
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  methyl 2(S)-ethoxy-3-{4-[2-(1-methyl-3-pentylureido)thiazol-5-yl]phenyl}propanoate 、 氢氧化锂 以0.05 g (86%) of 2(S)-ethoxy-3-{4-[2-(1-methyl-3-pentylureido)thiazol-5-yl]phenyl}propanoic acid is obtained in the form of a white solid with a melting point of 114° C.的产率得到2(S)-ethoxy-3-{4-[2-(1-methyl-3-pentylureido)thiazol-5-yl]phenyl}propanoic acid
  参考文献：
  名称：

  Compounds that modulate PPAR gamma-type receptors and cosmetic/pharmaceutical compositions comprising said compounds

  摘要：

  具有以下一般式（I）的新化合物在人类或兽医学中有广泛的应用（在皮肤病学、心血管疾病、免疫疾病和/或与脂质代谢有关的疾病领域），或者被制成化妆品配方中。

  公开号：

  US20100247468A1
• 作为产物：
  描述：

  methyl 2(S)-ethoxy-3-[4-(2-methylaminothiazol-5-yl)phenyl]propanoate 、 异氰酸戊酯 以0.06 g (26%) of methyl 2(S)-ethoxy-3-{4-[2-(1-methyl-3-pentylureido)thiazol-5-yl]phenyl}propanoate is obtained的产率得到methyl 2(S)-ethoxy-3-{4-[2-(1-methyl-3-pentylureido)thiazol-5-yl]phenyl}propanoate
  参考文献：
  名称：

  Compounds that modulate PPAR gamma-type receptors and cosmetic/pharmaceutical compositions comprising said compounds

  摘要：

  具有以下一般式（I）的新化合物在人类或兽医学中有广泛的应用（在皮肤病学、心血管疾病、免疫疾病和/或与脂质代谢有关的疾病领域），或者被制成化妆品配方中。

  公开号：

  US20100247468A1

文献信息

• [EN] NOVEL COMPOUNDS THAT MODULATE PPARgamma TYPE RECEPTORS, AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS<br/>[FR] NOUVEAUX COMPOSES QUI MODULENT LES RECEPTEURS DE TYPE PPAR DOLLAR G(G) ET UTILISATIONS DE CEUX-CI DANS DES COMPOSITIONS COSMETIQUES OU PHARMACEUTIQUES
  申请人：GALDERMA RES & DEV

  公开号：WO2004113331A1

  公开（公告）日：2004-12-29

  The invention relates to novel compounds corresponding to the general formula (I) below: (I) and also to the method for preparing them, and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism),-or alternatively in cosmetic compositions.

  该发明涉及与下列一般式（I）相对应的新化合物：（I），以及用于制备它们的方法，以及它们在用于人类或兽医药物组合物中的用途（在皮肤病学以及心血管疾病、免疫疾病和/或与脂质代谢有关的疾病领域），或者在化妆品组合物中的用途。
• Novel compounds that modulate PPARy type receptors and cosmetic/pharmaceutical compositions comprised thereof
  申请人：Clary Laurence

  公开号：US20060148862A1

  公开（公告）日：2006-07-06

  Novel compounds having the general formula (I) below: are useful in a wide variety of applications in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively are formulated into cosmetic compositions.

  具有以下一般式（I）的新化合物在人类或兽医学中具有广泛的应用（在皮肤病学中，以及在心血管疾病、免疫疾病和/或与脂质代谢有关的疾病领域），或者被制成化妆品组合物。
• METHODS OF MODULATING PPAR GAMMA-TYPE RECEPTORS
  申请人：CLARY Laurence

  公开号：US20100099689A1

  公开（公告）日：2010-04-22

  Novel compounds having the general formula (I) below: are useful in a wide variety of applications in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively are formulated into cosmetic compositions.

  具有以下一般式（I）的新化合物在人类或兽医学中具有广泛的应用（在皮肤科以及心血管疾病、免疫疾病和/或与脂质代谢相关的疾病领域），或者被制成化妆品组合物。
• Compounds that modulate PPARγ-type receptors and cosmetic/pharmaceutical compositions comprising said compounds
  申请人：Galderma Research & Development

  公开号：US07968560B2

  公开（公告）日：2011-06-28

  Novel compounds having the general formula (I) below: are useful in a wide variety of applications in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively are formulated into cosmetic compositions.

  具有以下通式（I）的新化合物在人类或兽医学中的广泛应用中具有用途（在皮肤科，以及心血管疾病，免疫疾病和/或与脂质代谢有关的领域），或者，可以制成化妆品组合物。
• Methods of modulating PPAR gamma-type receptors
  申请人：Galderma Research & Development

  公开号：US08022079B2

  公开（公告）日：2011-09-20

  Novel compounds having the general formula (I) below: are useful in a wide variety of applications in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively are formulated into cosmetic compositions.

  具有以下一般式（I）的新型化合物在人类或兽医学中有广泛的应用（在皮肤病学以及心血管疾病、免疫疾病和/或与脂质代谢相关的疾病领域），或者被制成化妆品组合物。