(2R,3R,E)-2,6-dihydroxy-3-((4-methoxybenzyloxy)methyl)-2-methylhex-4-enoic acid | 1187335-50-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: (2R,3R,E)-2,6-dihydroxy-3-((4-methoxybenzyloxy)methyl)-2-methylhex-4-enoic acid
• CAS: 1187335-50-7
• 化学式: C₁₆H₂₂O₆
• 分子量: 310.347
• InChiKey: YBENVZZQHRSFNK-UOYPKJBKSA-N

反应信息

• 作为反应物：
  描述：

  (2R,3R,E)-2,6-dihydroxy-3-((4-methoxybenzyloxy)methyl)-2-methylhex-4-enoic acid 在 四氧化锇 、 N-甲基吗啉氧化物 作用下， 以 二氯甲烷 、 叔丁醇 为溶剂， 反应 16.0h， 以50%的产率得到(3R,4S)-5-(1,2-dihydroxyethyl)-3-hydroxy-4-((4-methoxybenzyloxy)methyl)-3-methyldihydrofuran-2(3H)-one
  参考文献：
  名称：

  Silylene transfer to α-keto esters and application to the synthesis of γ-lactones

  摘要：

  Disubstituted alpha-hydroxy acids have been synthesized by metal-catalyzed silylene transfer to alpha-keto esters. A range of substituents are tolerated in the transformation with the exception of branched groups at the vinylic position. The alpha-hydroxy acid products can be converted into gamma-lactones using a variety of lactonization conditions. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.05.066