3,7-bis[(tert-butyldimethylsilyl)oxy]-4,8-dimethyl-9-oxoundecanoic acid methyl ester | 1039629-41-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3,7-bis[(tert-butyldimethylsilyl)oxy]-4,8-dimethyl-9-oxoundecanoic acid methyl ester
• CAS: 1039629-41-8
• 化学式: C₂₆H₅₄O₅Si₂
• 分子量: 502.883
• InChiKey: PMBFFEIUMINJNY-PABCKOPISA-N

反应信息

• 作为反应物：
  描述：

  3,7-bis[(tert-butyldimethylsilyl)oxy]-4,8-dimethyl-9-oxoundecanoic acid methyl ester 、 氯丙烯镁 、 叔丁基二甲基氯硅烷 、 异丁醛 以448 mg的产率得到3,7,13-tris[(tert-butyldimethylsilyl)oxy]-11-hydroxy-4,8,10,14-tetramethyl-9-oxopentadecanoic acid methyl ester
  参考文献：
  名称：

  Synthetic efforts toward the synthesis of octalactins

  摘要：

  Octalactin B was synthesized from the commercially available methyl-3-butenoate and isobutyraldehyde, using enantioselective allyl- and crotyltitanations to control the stereogenic centers at C3, C4, C7, C8, and C13. Moreover, the two other key-step reactions are a cross-metathesis reaction and a lactonization, using the effective anhydride MNBA, to build up the eight-membered ring lactone. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.04.026
• 作为产物：
  描述：

  3,7-bis[(tert-butyldimethylsilyl)oxy]-9-hydroxy-4,8-dimethylundecanoic acid methyl ester 在 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 为溶剂， 反应 2.5h， 以95%的产率得到3,7-bis[(tert-butyldimethylsilyl)oxy]-4,8-dimethyl-9-oxoundecanoic acid methyl ester
  参考文献：
  名称：

  Synthetic efforts toward the synthesis of octalactins

  摘要：

  Octalactin B was synthesized from the commercially available methyl-3-butenoate and isobutyraldehyde, using enantioselective allyl- and crotyltitanations to control the stereogenic centers at C3, C4, C7, C8, and C13. Moreover, the two other key-step reactions are a cross-metathesis reaction and a lactonization, using the effective anhydride MNBA, to build up the eight-membered ring lactone. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.04.026