6-O-tert-butyl 2-O-ethyl imidazo[1,2-a]pyrazine-2,6-dicarboxylate | 1075231-24-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-O-tert-butyl 2-O-ethyl imidazo[1,2-a]pyrazine-2,6-dicarboxylate
• CAS: 1075231-24-1
• 化学式: C₁₄H₁₇N₃O₄
• 分子量: 291.307
• InChiKey: YGYYZGTUCTYHCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  82.8
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  6-O-tert-butyl 2-O-ethyl imidazo[1,2-a]pyrazine-2,6-dicarboxylate 在 4-二甲氨基吡啶 氨 、 三乙胺 、 三氟乙酸 、 三氯乙酰氯 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 氯仿 、 水 为溶剂， 反应 8.0h， 生成 C₈H₄N₄O₂
  参考文献：
  名称：

  EP2360155

  摘要：

  公开号：
• 作为产物：
  描述：

  5-氯吡嗪-2-羧酸叔丁酯 在 氨 作用下， 以 1,4-二氧六环 、 DME (dimethoxyethane) 、 水 为溶剂， 反应 23.5h， 生成 6-O-tert-butyl 2-O-ethyl imidazo[1,2-a]pyrazine-2,6-dicarboxylate
  参考文献：
  名称：

  EP2360155

  摘要：

  公开号：

文献信息

• AMINODIHYDROTHIAZINE DERIVATIVES SUBSTITUTED WITH CYCLIC GROUPS
  申请人：Shionogi & Co., Ltd.

  公开号：EP2147914B1

  公开（公告）日：2014-06-04
• AMINODIHYDROTHIAZINE DERIVATIVES SUBSTITUTED WITH A CYCLIC GROUP
  申请人：Tamura Yuusuke

  公开号：US20100075957A1

  公开（公告）日：2010-03-25

  This invention provides a compound of the formula (I): wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R 1 is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl; R 2a and R 2b are each independently hydrogen, optionally substituted lower alkyl or optionally substituted acyl; R 3 a , R 3 b , R 3 c and R 3 d are each independently hydrogen, halogen, hydroxy or optionally substituted lower alkyl etc.; a pharmaceutically acceptable salt or solvate thereof, which is useful for treating diseases induced by production, secretion and/or deposition of amyloid β protein.
• 2-AMINOPYRIMIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVES BOTH HAVING BACE1-INHIBITING ACTIVITY
  申请人：Yonezawa Shuji

  公开号：US20110237576A1

  公开（公告）日：2011-09-29

  The present invention provides a compound which has an effect of inhibiting amyloid-β production and is useful as a therapeutic agent for diseases induced by production, secretion and/or deposition of amyloid-β proteins. The present invention relates to a compound represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein A is optionally substituted carbocyclic diyl or optionally substituted heterocyclic diyl; B is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R 1 is a group such as optionally substituted lower alkyl; R 2 is a group such as hydrogen; and R 3a and R 3b are each independently a group such as hydrogen, provided that the following compound is excluded.
• US8168630B2
  申请人：——

  公开号：US8168630B2

  公开（公告）日：2012-05-01
• US8507479B2
  申请人：——

  公开号：US8507479B2

  公开（公告）日：2013-08-13