1t.3-diphenyl-1c-p-tolyl-propen-(1)-one-(3) | 99143-01-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1t.3-diphenyl-1c-p-tolyl-propen-(1)-one-(3)
• 英文别名: 1t.3-Diphenyl-1c-p-tolyl-propen-(1)-on-(3)；(Z)-3-(4-methylphenyl)-1,3-diphenylprop-2-en-1-one
• CAS: 99143-01-8
• 化学式: C₂₂H₁₈O
• 分子量: 298.384
• InChiKey: BQNPXEBIUVFIPG-PGMHBOJBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3,5-diphenyl-3-(4-methylphenyl)-2(3H)-furanone 以 苯 为溶剂， 反应 3.0h， 以84%的产率得到1t.3-diphenyl-1c-p-tolyl-propen-(1)-one-(3)
  参考文献：
  名称：

  Sensitized photorearrangement of 3,3,5-triaryl-2(3H)-furanones to 3,4,5-triaryl-2(5H)-furanones. Steady-state and laser flash photolysis investigations

  摘要：

  DOI：

  10.1021/jo00389a034

文献信息

• Regio- and Stereoselective Synthesis of Multisubstituted Olefins and Conjugate Dienes by Using α-Oxo Ketene Dithioacetals as the Building Blocks
  作者：Weiwei Jin、Wangming Du、Qin Yang、Haifeng Yu、Jiping Chen、Zhengkun Yu

  DOI：10.1021/ol201620g

  日期：2011.8.19

  palladium(0)-catalyzed, Cu(I)-mediated synthetic route to trisubstituted olefins and conjugate dienes has been developed via oxo directing Liebeskind–Srogl cross-coupling reactions of gem-dihaloolefin-type α-oxo ketene dithioacetals with aryl and alkenylboronic acids. The synthetic protocol has demonstrated rare examples of transition-metal-promoted transformations of ketene dithioacetals, providing a novel route to

  一种有效的钯（0）催化，铜（I）介导的合成路线，以三取代的烯烃和共轭二烯已开发经由氧代引导利贝斯金德-Srogl交叉偶联反应的宝石-dihaloolefin型α氧代烯酮二硫与芳基和烯基硼酸。合成方案已证明了过渡金属促进的乙烯酮二硫缩醛转化的罕见实例，为高功能化的共轭二烯提供了一条新颖的途径。
• Photocatalytic Cross-Coupling of Aldehydes and Alkenes for Aryl Vinyl Ketones by a Single Catalyst
  作者：Chen-Hong Wang、Jia-Dong Guo、Ji-Xin Yu、Jia Qiao、Bin Chen、Chen-Ho Tung、Li-Zhu Wu

  DOI：10.1021/acs.orglett.4c02570

  日期：2024.8.16

  example of photocatalytic cross-coupling of alkenes with aldehydes by a single catalyst without an external photosensitizer and any additives. Irradiation of the aromatic aldehyde and cobaloxime catalyst results in the formation of an acyl radical, which undergoes radical addition with alkene or indole and subsequently β-H elimination to afford alkenyl ketone. The reaction features cheap and readily available

  这是通过单一催化剂实现烯烃与醛光催化交叉偶联的第一个例子，无需外部光敏剂和任何添加剂。芳香醛和钴肟催化剂的辐射导致酰基自由基的形成，酰基自由基与烯烃或吲哚发生自由基加成，随后消除β-H，得到烯基酮。该反应原料廉价易得，底物范围广泛，条件温和，甚至适用于生物活性化合物的后期衍生化。
• 97. Optical isomerism due to symmetrically placed hydrogen and deuterium atoms. Part II
  作者：G. R. Clemo、R. Raper、A. C. Robson

  DOI：10.1039/jr9390000431

  日期：——
• SINGH, G.;PURKAYASTHA, MAKHAN, L.;ILA, HIRIYAKKANAVAR;JUNJAPPA, HIRIYAKKA+, J. CHEM. SOC. PERKIN TRANS., 1985, N 7, 1289-1294
  作者：SINGH, G.、PURKAYASTHA, MAKHAN, L.、ILA, HIRIYAKKANAVAR、JUNJAPPA, HIRIYAKKA+

  DOI：——

  日期：——
• GOPIDAS K. R.; LOHRAY B. B.; RAJADURAI S.; DAS P. K.; GEORGE M. V., J. ORG. CHEM., 52,(1987) N 13, 2831-2838
  作者：GOPIDAS K. R.、 LOHRAY B. B.、 RAJADURAI S.、 DAS P. K.、 GEORGE M. V.

  DOI：——

  日期：——