N-(2-(5-chloro-2-(2-methoxy-5-(4H-1,2,4-triazol-4-yl)phenylamino)pyrimidin-4-ylamino)phenyl)methanesulfonamide | 1273072-57-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(2-(5-chloro-2-(2-methoxy-5-(4H-1,2,4-triazol-4-yl)phenylamino)pyrimidin-4-ylamino)phenyl)methanesulfonamide
• 英文别名: N-[2-[[5-chloro-2-[2-methoxy-5-(1,2,4-triazol-4-yl)anilino]pyrimidin-4-yl]amino]phenyl]methanesulfonamide
• CAS: 1273072-57-3
• 化学式: C₂₀H₁₉ClN₈O₃S
• 分子量: 486.942
• InChiKey: KRATVLXJZXOUGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  144
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• [EN] ORTHO SUBSTITUTED PYRIMIDINE COMPOUNDS AS JAK INHIBITORS<br/>[FR] COMPOSÉS DE PYRIMIDINE ORTHO-SUBSTITUÉS EN TANT QU'INHIBITEURS DE JAK
  申请人：CELLZOME LTD

  公开号：WO2011029807A1

  公开（公告）日：2011-03-17

  The present invention relates to compounds of formula (I), wherein X1 to X3, R, R2 to R7 and AA have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.

  本发明涉及化合物的结构式（I），其中X1到X3，R，R2到R7和AA的含义如描述和权利要求中所述。所述化合物可用作JAK抑制剂，用于治疗或预防免疫、炎症、自身免疫、过敏性疾病和免疫介导的疾病。本发明还涉及包括所述化合物的药物组合物、该类化合物的制备以及用作药物的用途。
• ORTHO SUBSTITUTED PYRIMIDINE COMPOUNDS AS JAK INHIBITORS
  申请人：Harrison Richard John

  公开号：US20120172385A1

  公开（公告）日：2012-07-05

  The invention relates to compounds of formula (I) wherein X 1 to X 3 , R, R 2 to R 7 and AA have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.

  本发明涉及公式(I)的化合物，其中X1至X3、R、R2至R7和AA的含义如说明书和权利要求中所述。所述化合物可用作JAK抑制剂，用于治疗或预防免疫、炎症、自身免疫、过敏性疾病和免疫介导疾病。本发明还涉及包括上述化合物的制药组合物、制备这些化合物以及用作药物的用途。