2-methyl-2-({1-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propyl]-1H-indazol-4-yl}oxy)propanoic acid | 748154-27-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-methyl-2-({1-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propyl]-1H-indazol-4-yl}oxy)propanoic acid
• 英文别名: 2-Methyl-2-[1-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propyl]indazol-4-yl]oxypropanoic acid
• CAS: 748154-27-0
• 化学式: C₂₄H₂₅N₃O₄
• 分子量: 419.48
• InChiKey: TYHLVFZUSAEONF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  90.4
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] OXAZOLE-DERIVATIVES AS PPAR AGONISTS<br/>[FR] DERIVES D'OXAZOLE UTILISES EN TANT QU'AGONISTES DE PPAR
  申请人：PFIZER

  公开号：WO2004074284A1

  公开（公告）日：2004-09-02

  Fused heteroaryl carboxylic acids of formula (I): wherein R1, Ar, A, Y, HET, Q, and T are as defined in the specification; pharmaceutical compositions containing effective amounts of said compounds or their salts are useful for treating PPAR related disorders, such as diabetes, dyslipidemia, obesity and inflammatory disorders.

  式(I)的融合杂环羧酸：其中R1、Ar、A、Y、HET、Q和T如规范中定义；含有所述化合物或其盐的有效量的药物组合物对于治疗PPAR相关疾病，如糖尿病、血脂异常、肥胖和炎症性疾病是有用的。
• Fused heteroaryl carboxylic acids as PPAR agonists
  申请人：Agouron Pharmaceuticals, Inc.

  公开号：US20040209929A1

  公开（公告）日：2004-10-21

  Fused heteroarylcarboxylic acids of formula (I): 1 wherein R 1 , Ar, A, Y, HET, Q, and T are as defined in the specification; pharmaceutical compositions containing effective amounts of said compounds or their salts are useful for treating PPAR related disorders, such as diabetes, dyslipidemia, obesity and inflammatory disorders.

  式(I)的融合杂环羧酸：其中R1、Ar、A、Y、HET、Q和T的定义见说明书；含有该化合物或其盐的有效量的制药组合物可用于治疗与PPAR相关的疾病，如糖尿病、血脂异常、肥胖和炎症性疾病。
• OXAZOLE-DERIVATIVES AS PPAR AGONISTS
  申请人：PFIZER INC.

  公开号：EP1597257A1

  公开（公告）日：2005-11-23