(2E)-3-(1-methyl-1H-imidazol-4-yl)prop-2-enoic acid hydrochloride, E | 479028-75-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (2E)-3-(1-methyl-1H-imidazol-4-yl)prop-2-enoic acid hydrochloride, E
• 英文别名: (E)-3-(1-methylimidazol-4-yl)prop-2-enoic acid;hydrochloride
• CAS: 479028-75-6
• 化学式: C7H9ClN2O2
• 分子量: 188.61
• InChiKey: WVHBRHOUQUGHKG-SQQVDAMQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.94
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Condensed thiazole compounds, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0443588A1

  公开（公告）日：1991-08-28

  A novel condensed thiazole derivative of the formula [I]: wherein A is a single bond or CH₂; R¹ is hydrogen atom, or an optionally substituted aliphatic, carboxylic acyl or sulfonic acyl group; and R² is hydrogen atom, or an optionally substituted aromatic cyclic or aliphatic group, or a salt thereof. The compound [I] is useful for medicines for preventing and treating various diseases such as cancer, arterial sclerosis, hepatopathy, cerebrovascular diseases, inflammatory and the like. A process of the compound of the formula [I] or a salt thereof and a pharmaceutical composition comprising the compound of the formula [I] or a pharmaceutically acceptable salt thereof as an active component are also disclosed.

  式 [I] 的新型缩合噻唑衍生物： 其中 A 为单键或 CH₂；R¹ 为氢原子或任选取代的脂肪族、羧酰基或磺酰基；R² 为氢原子或任选取代的芳香环基或脂肪族基团，或其盐。化合物[I]可用于预防和治疗各种疾病，如癌症、动脉硬化、肝病、脑血管疾病、炎症等。本发明还公开了式[I]化合物或其盐的制备工艺以及包含式[I]化合物或其药学上可接受的盐作为活性成分的药物组合物。
• US5153201A
  申请人：——

  公开号：US5153201A

  公开（公告）日：1992-10-06