2-(nonafluorobutanesulfonyloxy)benzophenone | 767288-76-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(nonafluorobutanesulfonyloxy)benzophenone
• CAS: 767288-76-6
• 化学式: C₁₇H₉F₉O₄S
• 分子量: 480.308
• InChiKey: CLKBXOWWBDLZKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.05
• 重原子数：
  31.0
• 可旋转键数：
  7.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  60.44
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  2-(nonafluorobutanesulfonyloxy)benzophenone 在 1,1'-双(二苯基膦)二茂铁 、 palladium diacetate 盐酸羟胺 、 caesium carbonate 作用下， 以 1,4-二氧六环 、 乙醇 为溶剂， 反应 49.5h， 生成 3-phenyl-1,2-benzisoxazole
  参考文献：
  名称：

  Synthesis of 3-substituted indazoles and benzoisoxazoles via Pd-catalyzed cyclization reactions: application to the synthesis of nigellicine

  摘要：

  Syntheses of 3-substituted indazoles and benzoisoxazoles were efficiently accomplished with the aid of Pd-catalyzed intramolecular carbon-nitrogen and carbon-oxygen bond formations. The catalyst system described herein allows the cyclization to proceed under very mild conditions and thus could be applied to a wide range of substrates with acid- or base-sensitive functional groups. A total synthesis for the indazole ring-containing natural product nigellicine is also described. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.01.010
• 作为产物：
  描述：

  2-羟基二苯甲酮 、 全氟丁基磺酰氟 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 23.0h， 以92%的产率得到2-(nonafluorobutanesulfonyloxy)benzophenone
  参考文献：
  名称：

  Synthesis of 3-substituted indazoles and benzoisoxazoles via Pd-catalyzed cyclization reactions: application to the synthesis of nigellicine

  摘要：

  Syntheses of 3-substituted indazoles and benzoisoxazoles were efficiently accomplished with the aid of Pd-catalyzed intramolecular carbon-nitrogen and carbon-oxygen bond formations. The catalyst system described herein allows the cyclization to proceed under very mild conditions and thus could be applied to a wide range of substrates with acid- or base-sensitive functional groups. A total synthesis for the indazole ring-containing natural product nigellicine is also described. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.01.010

文献信息

• Efficient Synthesis of 3-Substituted Indazoles Using Pd-Catalyzed Intramolecular Amination Reaction of<i>N</i>-Tosylhydrazones
  作者：Kiyofumi Inamoto、Mika Katsuno、Takashi Yoshino、Ikue Suzuki、Kou Hiroya、Takao Sakamoto

  DOI：10.1246/cl.2004.1026

  日期：2004.8

  The efficient method for the preparation of 3-substituted indazoles was developed using the palladium catalyzed intramolecular amination reaction of 2-bromophenyl hydrazone derivatives. Good functional group compatibility was observed under mild reaction conditions and various 3-substituted indazoles were obtained in moderate to excellent yield.

  利用钯催化的2-溴苯腙衍生物的分子内胺化反应开发了制备3-取代吲唑的有效方法。在温和的反应条件下观察到良好的官能团相容性，并以中等至优异的收率获得了各种3-取代吲唑。