(Z)-N-(4-(2-((3-fluorophenyl)imino)-3-(furan-2-ylmethyl)-4-oxothiazolidin-5-yl)phenyl)acetamide | 1264909-45-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-N-(4-(2-((3-fluorophenyl)imino)-3-(furan-2-ylmethyl)-4-oxothiazolidin-5-yl)phenyl)acetamide
• CAS: 1264909-45-6
• 化学式: C₂₂H₁₈FN₃O₃S
• 分子量: 423.468
• InChiKey: INNKNYXZLTYZFT-LVWGJNHUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.88
• 重原子数：
  30.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  74.91
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  (Z)-N-(4-(2-((3-fluorophenyl)imino)-3-(furan-2-ylmethyl)-4-oxothiazolidin-5-yl)phenyl)acetamide 、 溶剂黄146 在 copper diacetate 、 manganese triacetate 作用下， 以59%的产率得到(Z)-N-(4-(2-((3-fluorophenyl)imino)-3-(furan-2-ylmethyl)-4-oxothiazolidin-5-yl)phenyl)acetamide
  参考文献：
  名称：

  Inhibitors of HCV NS5A: From Iminothiazolidinones to Symmetrical Stilbenes

  摘要：

  The iminothiazolidinone BMS-858 (2) was identified as a specific inhibitor of HCV replication in a genotype 1b replicon assay via a high-throughput screening campaign. A more potent analogue, BMS-824 (18), was used in resistance mapping studies, which revealed that inhibitory activity was related to disrupting the function of the HCV nonstructural protein 5A. Despite the development of coherent and interpretable SAIL, it was subsequently discovered that in DMSO 18 underwent an oxidation and structural rearrangement to afford the thiohydantoin 47, a compound with reduced HCV inhibitory activity. However, HPLC bioassay fractionation studies performed after incubation of 18 in assay media led to the identification of fractions containing a dimeric species 48 that exhibited potent antiviral activity. Excision of the key elements hypothesized to be responsible for antiviral activity based on SAR observations reduced 48 to a simplified, symmetrical, pharmacophore realized most effectively with the stilbene 55, a compound that demonstrated potent inhibition of HCV in a genotype 1b replicon with an EC50 = 86 pM.

  DOI：

  10.1021/ml1002647
• 作为产物：
  描述：

  (+/-)-α-bromo-p-azidophenylacetic acid ethyl ester 在 N-甲基吗啉 、 tin(II) chloride dihdyrate 、 sodium acetate 作用下， 以 乙醇 、 二氯甲烷 、 乙酸乙酯 为溶剂， 生成 (Z)-N-(4-(2-((3-fluorophenyl)imino)-3-(furan-2-ylmethyl)-4-oxothiazolidin-5-yl)phenyl)acetamide
  参考文献：
  名称：

  Inhibitors of HCV NS5A: From Iminothiazolidinones to Symmetrical Stilbenes

  摘要：

  The iminothiazolidinone BMS-858 (2) was identified as a specific inhibitor of HCV replication in a genotype 1b replicon assay via a high-throughput screening campaign. A more potent analogue, BMS-824 (18), was used in resistance mapping studies, which revealed that inhibitory activity was related to disrupting the function of the HCV nonstructural protein 5A. Despite the development of coherent and interpretable SAIL, it was subsequently discovered that in DMSO 18 underwent an oxidation and structural rearrangement to afford the thiohydantoin 47, a compound with reduced HCV inhibitory activity. However, HPLC bioassay fractionation studies performed after incubation of 18 in assay media led to the identification of fractions containing a dimeric species 48 that exhibited potent antiviral activity. Excision of the key elements hypothesized to be responsible for antiviral activity based on SAR observations reduced 48 to a simplified, symmetrical, pharmacophore realized most effectively with the stilbene 55, a compound that demonstrated potent inhibition of HCV in a genotype 1b replicon with an EC50 = 86 pM.

  DOI：

  10.1021/ml1002647