2-[1-(3,4-dichlorophenyl)-5-methyl-1H-1,2,4-triazol-3-yl-sulfonyl]-N,N-diethylethanamine | 1025011-37-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[1-(3,4-dichlorophenyl)-5-methyl-1H-1,2,4-triazol-3-yl-sulfonyl]-N,N-diethylethanamine
• 英文别名: 2-[[1-(3,4-dichlorophenyl)-5-methyl-1,2,4-triazol-3-yl]sulfonyl]-N,N-diethylethanamine
• CAS: 1025011-37-3
• 化学式: C₁₅H₂₀Cl₂N₄O₂S
• 分子量: 391.321
• InChiKey: CADMZMJQQLJLLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  76.5
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• 1,2,4-Triazole derivatives as sigma receptor inhibitors
  申请人：Laboratorios del Dr. Esteve S.A.

  公开号：EP1921073A1

  公开（公告）日：2008-05-14

  The invention relates to the use of compounds having pharmacological activity towards the sigma receptor, and more particularly to 1,2,4-triazole derivatives of formula I to processes of preparation of such compounds and to pharmaceutical compositions comprising them.

  该发明涉及使用具有对西格玛受体具有药理活性的化合物，更特别地涉及1,2,4-三唑衍生物的制备方法及包含它们的药物组合物。
• Sigma ligands for use in the prevention and/or treatment of postoperative pain
  申请人：Laboratorios del. Dr. Esteve, S.A.

  公开号：EP2353598A1

  公开（公告）日：2011-08-10

  The invention refers to the use of a sigma ligand, particularly a sigma ligand of formulae (I), (II) or (III) to prevent and/or treat acute and chronic pain developed as a consequence of surgery, especially superficial and/or deep pain secondary to surgical tissue injury, and peripheral neuropathic pain, neuralgia, allodynia, causalgia, hyperalgesia, hyperesthesia, hyperpathia, neuritis or neuropathy secondary to surgical procedure.

  本发明涉及使用sigma配体，特别是公式（I），（II）或（III）的sigma配体，以预防和/或治疗由手术引起的急性和慢性疼痛，特别是手术组织损伤引起的表浅和/或深层疼痛，以及周围神经病理性疼痛，神经痛，触痛，烧伤性痛，痛觉过敏，疼痛过敏，神经炎或手术过程引起的神经病变。
• 1,2,4-TRIAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS
  申请人：Jagerovic Nadine

  公开号：US20100004224A1

  公开（公告）日：2010-01-07

  The invention relates to the use of compounds having pharmacological activity towards the sigma receptor, and more particularly to 1,2,4-triazole derivatives of formula (I) to processes of preparation of such compounds and to pharmaceutical compositions comprising them.

  该发明涉及使用对sigma受体具有药理活性的化合物，更具体地涉及公式（I）的1,2,4-三唑衍生物的制备过程以及包含它们的制药组合物。
• SIGMA LIGANDS FOR USE IN THE PREVENTION AND/OR TREATMENT OF POSTOPERATIVE PAIN
  申请人：Laboratorios del. Dr. Esteve, S.A.

  公开号：EP2531191A1

  公开（公告）日：2012-12-12
• SIGMA LIGANDS FOR USE IN THE PREVENTION AND/OR TREATMENT OF POST-OPERATIVE PAIN
  申请人：Vela Hernández José Miguel

  公开号：US20120302568A1

  公开（公告）日：2012-11-29

  The invention refers to the use of a sigma ligand, particularly a sigma ligand of formulae (I), (II) or (III) to prevent and/or treat acute and chronic pain developed as a consequence of surgery, especially superficial and/or deep pain secondary to surgical tissue injury, and peripheral neuropathic pain, neuralgia, allodynia, causalgia, hyperalgesia, hyperesthesia, hyperpathia, neuritis or neuropathy secondary to surgical procedure.