methyl 5-(aminomethyl)-1-methyl-1H-pyrrole-2-carboxylate | 1006618-93-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: methyl 5-(aminomethyl)-1-methyl-1H-pyrrole-2-carboxylate
• 英文别名: methyl 5-(aminomethyl)-1-methylpyrrole-2-carboxylate
• CAS: 1006618-93-4
• 化学式: C₈H₁₂N₂O₂
• 分子量: 168.195
• InChiKey: CVPFVCOVAVTOMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  57.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  methyl 5-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-1-methyl-1H-pyrrole-2-carboxylate 在 一水合肼 作用下， 以 甲醇 、 氯仿 为溶剂， 生成 methyl 5-(aminomethyl)-1-methyl-1H-pyrrole-2-carboxylate
  参考文献：
  名称：

  EP2050446

  摘要：

  公开号：

文献信息

• SULFONAMIDE COMPOUND OR SALT THEREOF
  申请人：Kubota Hideki

  公开号：US20090312328A1

  公开（公告）日：2009-12-17

  [Object] A compound that can be used as an agent for treating a disease associated with an EP1 receptor, in particular, a lower urinary tract symptom. [Means for Solution] It was confirmed that a sulfonamide compound having an amide structure and characterized by a chemical structure in which a carbon atom in the amide bonds to the N atom in sulfonamide through lower alkylene, or a salt thereof, has a potent EP1 receptor antagonistic activity, accomplishing the present invention. Since the sulfonamide compound of the present invention or a pharmaceutically acceptable salt thereof has a potent EP1 receptor antagonistic activity, it is useful as an agent for treating a disease associated with an EP1 receptor, in particular, a lower urinary tract symptom.

  [物品] 一种化合物，可用作治疗与EP1受体相关的疾病的药剂，特别是下尿路症状的药剂。 [解决方案的手段] 确认了一种磺酰胺化合物，具有酰胺结构，其化学结构中的碳原子通过较低的烷基与磺酰胺中的N原子结合，或其盐，具有强大的EP1受体拮抗活性，从而实现了本发明。由于本发明的磺酰胺化合物或其药学上可接受的盐具有强大的EP1受体拮抗活性，因此它可用作治疗与EP1受体相关的疾病的药剂，特别是下尿路症状的药剂。
• Sulfonamide compound or salt thereof
  申请人：Astellas Pharma Inc.

  公开号：US07973078B2

  公开（公告）日：2011-07-05

  A compound that can be used as an agent for treating a disease associated with an EP1 receptor, in particular a lower urinary tract symptom. It was confirmed that a sulfonamide compound having an amide structure and characterized by a chemical structure in which a carbon atom in the amide bonds to the N atom in sulfonamide through lower alkylene, or a salt thereof, has a potent EP1 receptor antagonistic activity, accomplishing the present invention. Since the sulfonamide compound of the present invention or a pharmaceutically acceptable salt thereof has a potent EP1 receptor antagonistic activity, it is useful as an agent for treating a disease associated with an EP1 receptor, in particular, a lower urinary tract symptom.

  一种可用作治疗与EP1受体相关疾病的化合物，特别是下泌尿道症状的药剂。经确认，一种具有酰胺结构的磺酰胺化合物，其化学结构中酰胺中的碳原子通过较低的烷基与磺酰胺中的N原子结合，或其盐，具有强大的EP1受体拮抗活性，实现了本发明。由于本发明的磺酰胺化合物或其药学上可接受的盐具有强大的EP1受体拮抗活性，因此它可用作治疗与EP1受体相关疾病的药剂，特别是下泌尿道症状。
• EP2050446B1
  申请人：——

  公开号：EP2050446B1

  公开（公告）日：2014-05-07
• US7973078B2
  申请人：——

  公开号：US7973078B2

  公开（公告）日：2011-07-05
• EP2050446
  申请人：——

  公开号：——

  公开（公告）日：——