2-chloro-5-[4-(3-isocyano-phenyl)-[1,2,3]triazol-1-yl]-pyridine | 1215004-91-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-chloro-5-[4-(3-isocyano-phenyl)-[1,2,3]triazol-1-yl]-pyridine
• 英文别名: 2-Chloro-5-[4-(3-isocyanophenyl)triazol-1-yl]pyridine
• CAS: 1215004-91-3
• 化学式: C₁₄H₈ClN₅
• 分子量: 281.704
• InChiKey: KSWJMQQKCYBKNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  48
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• TRIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS
  申请人：NeuroSearch A/S

  公开号：EP2324007B1

  公开（公告）日：2012-08-15
• [EN] TRIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS<br/>[FR] DÉRIVÉS DE TRIAZOLE ET LEUR UTILISATION EN TANT QUE MODULATEURS DE RÉCEPTEUR NICOTINIQUE D'ACÉTYLCHOLINE
  申请人：NEUROSEARCH AS

  公开号：WO2010026134A1

  公开（公告）日：2010-03-11

  This invention relates to novel triazole derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.