2-Ethyl-5-thiazolemethanamine | 1183523-89-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-Ethyl-5-thiazolemethanamine
• 英文别名: (2-ethyl-1,3-thiazol-5-yl)methanamine
• CAS: 1183523-89-8
• 化学式: C₆H₁₀N₂S
• 分子量: 142.22
• InChiKey: VVGHFFICVOVLNB-UHFFFAOYSA-N

物化性质

• 沸点：
  236℃
• 密度：
  1.138
• 闪点：
  96℃

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  67.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Hepatitis B core protein allosteric modulators
  申请人：Indiana University Research and Technology Corporation

  公开号：US10183936B2

  公开（公告）日：2019-01-22

  The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

  本公开内容部分提供了对乙型肝炎病毒 Cp 具有异生效应特性的化合物。本文还提供了治疗病毒感染（如乙型肝炎）的方法，包括向有需要的患者施用所公开的化合物。
• HEPATITIS B CORE PROTEIN ALLOSTERIC MODULATORS
  申请人：INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY

  公开号：US20170015658A1

  公开（公告）日：2017-01-19

  The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
• PROCESS FOR MAKING HEPATITIS B CORE PROTEIN MODULATORS
  申请人：Assembly Biosciences, Inc.

  公开号：US20210380577A1

  公开（公告）日：2021-12-09

  The present disclosure provides, in part, a process for preparing compounds (I) having allosteric effector properties against Hepatitis B virus Cp.