1-[3-cyano-1-(cyclopropylmethyl)indol-5-yl]-3-methyl-pyrazole-4-carboxylic acid | 1287766-67-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-[3-cyano-1-(cyclopropylmethyl)indol-5-yl]-3-methyl-pyrazole-4-carboxylic acid
• 英文别名: 1-[3-Cyano-1-(cyclopropylmethyl)indol-5-yl]-3-methylpyrazole-4-carboxylic acid
• CAS: 1287766-67-9
• 化学式: C₁₈H₁₆N₄O₂
• 分子量: 320.351
• InChiKey: FJLOXIFWHOUVKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  83.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• NOVEL COMPOUNDS EFFECTIVE AS XANTHINE OXIDASE INHIBITORS, METHOD FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
  申请人：Song Jeong Uk

  公开号：US20120184582A1

  公开（公告）日：2012-07-19

  The present invention relates to novel compounds which are effective as an inhibitor for xanthine oxidase, a process for preparing the same, and a pharmaceutical composition comprising a therapeutically effective amount of the same.

  本发明涉及一种新型化合物，其作为黄嘌呤氧化酶抑制剂具有有效性，以及制备该化合物的方法和包含其治疗有效剂量的制药组合物。
• COMPOUNDS EFFECTIVE AS XANTHINE OXIDASE INHIBITORS, METHOD FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
  申请人：LG Life Sciences Ltd

  公开号：EP2467378B1

  公开（公告）日：2016-07-27
• US8729273B2
  申请人：——

  公开号：US8729273B2

  公开（公告）日：2014-05-20
• [EN] NOVEL COMPOUNDS EFFECTIVE AS XANTHINE OXIDASE INHIBITORS, METHOD FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME<br/>[FR] NOUVEAUX COMPOSÉS EFFICACES COMME INHIBITEURS DE LA XANTHINE OXYDASE, LEUR PROCÉDÉ DE PRÉPARATION ET COMPOSITION PHARMACEUTIQUE LES CONTENANT
  申请人：LG LIFE SCIENCES LTD

  公开号：WO2011043568A2

  公开（公告）日：2011-04-14

  The present invention relates to novel compounds which are effective as an inhibitor for xanthine oxidase, a process for preparing the same, and a pharmaceutical composition comprising a therapeutically effective amount of the same.