5-[4-[4-[4-[4-[4-[4-[[2-(2-carboxyethyl)-5-hydroxy]benzyl]-[2-(2-carboxyethyl)-5-hydroxy]benzyl]-[2-(2-carboxyethyl)-5-hydroxy]benzyl]-[2-(2-carboxyethyl)-5-hydroxy]benzyl]-[2-(2-carboxyethyl)-5-hydroxy]benzyl]-[2-(2-carboxyethyl)-5-hydroxy]benzyl]-[2-(2-carboxyethyl)-5-hydroxy]benzyl]-4-hydroxy-2-methylhydrocinnamic acid | 147067-99-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 5-[4-[4-[4-[4-[4-[4-[[2-(2-carboxyethyl)-5-hydroxy]benzyl]-[2-(2-carboxyethyl)-5-hydroxy]benzyl]-[2-(2-carboxyethyl)-5-hydroxy]benzyl]-[2-(2-carboxyethyl)-5-hydroxy]benzyl]-[2-(2-carboxyethyl)-5-hydroxy]benzyl]-[2-(2-carboxyethyl)-5-hydroxy]benzyl]-[2-(2-carboxyethyl)-5-hydroxy]benzyl]-4-hydroxy-2-methylhydrocinnamic acid
• 英文别名: 3-[2-[[5-(2-Carboxyethyl)-4-[[5-(2-carboxyethyl)-4-[[5-(2-carboxyethyl)-4-[[5-(2-carboxyethyl)-4-[[5-(2-carboxyethyl)-4-[[5-(2-carboxyethyl)-4-[[5-(2-carboxyethyl)-2-hydroxy-4-methylphenyl]methyl]-2-hydroxyphenyl]methyl]-2-hydroxyphenyl]methyl]-2-hydroxyphenyl]methyl]-2-hydroxyphenyl]methyl]-2-hydroxyphenyl]methyl]-2-hydroxyphenyl]methyl]-4-hydroxyphenyl]propanoic acid
• CAS: 147067-99-0
• 化学式: C₈₀H₈₂O₂₄
• 分子量: 1427.52
• InChiKey: WPKJLWAHCOSAAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11
• 重原子数：
  104
• 可旋转键数：
  38
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  460
• 氢给体数：
  16
• 氢受体数：
  24

文献信息

• AROMATIC OLIGOMERIC COMPOUNDS USEFUL AS MIMICS OF BIOACTIVE MACROMOLECULES
  申请人：RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC.

  公开号：EP0585371A1

  公开（公告）日：1994-03-09
• EP0585371A4
  申请人：——

  公开号：EP0585371A4

  公开（公告）日：1994-07-13
• US5571506A
  申请人：——

  公开号：US5571506A

  公开（公告）日：1996-11-05
• [EN] AROMATIC OLIGOMERIC COMPOUNDS USEFUL AS MIMICS OF BIOACTIVE MACROMOLECULES
  申请人：RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC.

  公开号：WO1992020350A1

  公开（公告）日：1992-11-26

  (EN) This invention relates to aromatic oligomeric compounds useful in the treatment of cardiovascular, bone metabolic, hypolipidaemic, neuronal, gastrointestinal and elastase-mediated connective tissue degradation disorders and disorders which may be treated by agents effective in binding DNA, or abnormal smooth muscle cell proliferation, to processes for preparation of such oligomeric compounds, to pharmaceutical compositions including such oligomeric compounds, and their use in the treatment of such disorders.(FR) L'invention concerne des composés oligomères aromatiques utiles dans le traitement de troubles cardio-vasculaires, métaboliques osseux, hypolipidémiques, neuronaux, gastrointestinaux et de dégradation des tissus connectifs induite par élastase ainsi que des troubles qui peuvent être traités par des agents efficaces dans la liaison d'ADN, ou une prolifération anormale des cellules des muscles lisses, l'invention concernant également des procédés de préparation de ces composés oligomères, des compositions pharmaceutiques contenant ces composés oligomères ainsi que leur utilisation dans le traitement de tels troubles.