1,1-dimethylethyl (1aS-(1aα,8β,8aα,8bα))-(8-{[(aminocarbonyl)oxy]methyl}-1,1a,2,8,8a,8b-hexahydro-4-hydroxy-8a-methoxy-5-methyl-7-oxoazirino[2',3':3,4]pyrrolo[1,2-a]indol-6(7H)-ylidene)hydrazinecarboxylate | 117606-67-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1,1-dimethylethyl (1aS-(1aα,8β,8aα,8bα))-(8-{[(aminocarbonyl)oxy]methyl}-1,1a,2,8,8a,8b-hexahydro-4-hydroxy-8a-methoxy-5-methyl-7-oxoazirino[2',3':3,4]pyrrolo[1,2-a]indol-6(7H)-ylidene)hydrazinecarboxylate
• CAS: 117606-67-4
• 化学式: C₂₀H₂₇N₅O₇
• 分子量: 449.464
• InChiKey: QOODKRPRKYFXQH-FFPJLZTQSA-N

反应信息

• 作为产物：
  描述：

  肼基甲酸叔丁酯 、 mitomycin A 以 甲醇 为溶剂， 以72%的产率得到1,1-dimethylethyl (1aS-(1aα,8β,8aα,8bα))-(8-{[(aminocarbonyl)oxy]methyl}-1,1a,2,8,8a,8b-hexahydro-4-hydroxy-8a-methoxy-5-methyl-7-oxoazirino[2',3':3,4]pyrrolo[1,2-a]indol-6(7H)-ylidene)hydrazinecarboxylate
  参考文献：
  名称：

  Mitomycin C analogs with a substituted hydrazine at position 7. Synthesis, spectral properties, and biological activity

  摘要：

  A select number of mitomycin C derivatives with a substituted hydrazine group at position 7 were synthesized and tested for antineoplastic activity by using an in vivo test with murine P388 leukemia. Several of the adducts displayed activity comparable to that of mitomycin C. The X-ray-determined crystal structure of one of the derivatives (3f) is reported.

  DOI：

  10.1021/jm00121a044