(2S,4S)-4-sec-butyl-5,5-diethyl-2-p-tolyloxazolidine | 1173393-93-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S,4S)-4-sec-butyl-5,5-diethyl-2-p-tolyloxazolidine
• 英文别名: (2S,4S)-4-butan-2-yl-5,5-diethyl-2-(4-methylphenyl)-1,3-oxazolidine
• CAS: 1173393-93-5
• 化学式: C₁₈H₂₉NO
• 分子量: 275.434
• InChiKey: NAJHUUXCQMKEIT-HGVHAKBWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• OXAZOLIDINE DERIVATIVES AS NMDA ANTAGONISTS
  申请人：Ip Nancy Yuk-Yu

  公开号：US20110144168A1

  公开（公告）日：2011-06-16

  The present invention provides therapeutically active oxazolidine derivatives and compositions as NMDA antagonists, which are useful in preventing and treating central nervous system disorders by inhibiting over-activation of NMDA receptors. In one aspect, the present invention provides methods of treating and/or preventing neurodegenerative diseases and neuropathological disorders, methods of providing neuroprotection under stress conditions such as a stroke, and methods of enhancing the brain's cognitive functions in mammals and humans. For example, the compounds can prevent glutamate-induced neuro-toxicity by inhibiting the activities of the NMDA receptor in the presence of toxic doses of NMDA. In addition, the compounds can potentiate the calcium current in the presence of low dose of NMDA.
• US8722714B2
  申请人：——

  公开号：US8722714B2

  公开（公告）日：2014-05-13
• [EN] OXAZOLIDINE DERIVATIVES AS NMDA ANTAGONISTS<br/>[FR] DÉRIVÉS D'OXAZOLIDINE UTILISÉS EN TANT QU'ANTAGONISTES DE NMDA
  申请人：UNIV HONG KONG SCIENCE & TECHN

  公开号：WO2009092324A1

  公开（公告）日：2009-07-30

  The present invention provides therapeutically active oxazolidine derivatives and compositions as NMDA antagonists, which are useful in preventing and treating central nervous system disorders by inhibiting over-activation of NMDA receptors. In one aspect, the present invention provides methods of treating and/or preventing neurodegenerative diseases and neuropathological disorders, methods of providing neuroprotection under stress conditions such as a stroke, and methods of enhancing the brain's cognitive functions in mammals and humans. For example, the compounds can prevent glutamate-induced neuro- toxicity by inhibiting the activities of the NMDA receptor in the presence of toxic doses of NMDA. In addition, the compounds can potentiate the calcium current in the presence of low dose of NMDA.