3-Hydroxy-2-(2,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one | 649552-05-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 3-Hydroxy-2-(2,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one
• 英文别名: 3-hydroxy-2-(2,4,5-trihydroxyphenyl)chromen-4-one
• CAS: 649552-05-6
• 化学式: C₁₅H₁₀O₆
• 分子量: 286.24
• InChiKey: FLSDDKHESFODKK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• [EN] STREPTOCOCCUS MUTANS GLUCOSYL TRANSFERASE INHIBITORS FOR DENTAL CARIES THERAPY<br/>[FR] INHIBITEURS DE GLUCOSYLE TRANSFÉRASE DE STREPTOCOCCUS MUTANS POUR LA THÉRAPIE DES CARIES DENTAIRES
  申请人：UAB RESEARCH FOUNDATION

  公开号：WO2019195430A1

  公开（公告）日：2019-10-10

  The present invention is related to the inhibition of the formation of Streptococci biofilms through the inhibition of glucosyl transferase (Gtf). Compounds, compositions and methods for inhibiting Streptococcus biofilm formation, as well as for preventing, inhibiting and/or treating the formation of dental caries, and methods of identifying compounds that prevent, inhibit and/or treat the formation of dental caries are provided.

  本发明涉及通过抑制葡萄糖基转移酶(Gtf)来抑制链球菌生物膜形成的方法。提供了用于抑制链球菌生物膜形成的化合物、组合物和方法，以及用于预防、抑制和/或治疗龋齿形成的方法，以及用于识别能够预防、抑制和/或治疗龋齿形成的化合物的方法。
• Flavonoid compounds as therapeutic antioxidants
  申请人：Caldwell Thomas Stuart

  公开号：US20060137207A1

  公开（公告）日：2006-06-29

  Novel flavonoid compounds having anti-oxidant activity are described. Formula 1. The compounds have been shown to exhibit anti-oxidative properties in biological systems and their utility in a sunscreen or skincare composition or to treat conditions involving oxidative damage, especially curative or prophylactic treatment of Alzheimer's disease or ischaemia-reperfusion injury, is described.

  描述了具有抗氧化活性的新型黄酮类化合物。公式1。已经证明这些化合物在生物系统中表现出抗氧化性质，并描述了它们在防晒霜或护肤组合物中的实用性，或用于治疗涉及氧化损伤的疾病，特别是治疗阿尔茨海默病或缺血再灌注损伤的治疗或预防。
• COMPOUNDS
  申请人：Kong Thoo Lin Paul

  公开号：US20100151508A1

  公开（公告）日：2010-06-17

  Flavonoid-type compounds of the Formula (II); in which R 1 is alkyl C 2 to C 20 , R 2 , R 3 , R 4 and R 5 are any one or more of hydrogen, alkyl, alkenyl, alkynyl, phenyl or benzyl, especially 7-decyl-3-hydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopy-ran-4-one or 7-ethyl-3-hydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one provide fluorescent probes and antioxidants, and are useful in discriminating healthy and stressed cells.

  公式（II）中的黄酮类化合物;其中R1是烷基C2到C20，R2，R3，R4和R5是氢，烷基，烯基，炔基，苯基或苄基中的任何一个或多个，特别是7-癸基-3-羟基-2-（3,4,5-三羟基苯基）-4H-1-苯并吡喃-4-酮或7-乙基-3-羟基-2-（3,4,5-三羟基苯基）-4H-1-苯并吡喃-4-酮提供荧光探针和抗氧化剂，并且对于区分健康和受压力细胞非常有用。
• FLAVONOID COMPOUNDS AS THERAPEUTIC ANTIOXIDANTS
  申请人：The Rowett Research Institute

  公开号：EP1534698B1

  公开（公告）日：2007-09-19
• IN VITRO PRESERVATION OF LIVING ANIMAL CELLS AND COMPOUNDS SUITABLE FOR USE IN THE PRESERVATION OF LIVING ANIMAL CELLS
  申请人：McPhail Donald Barton

  公开号：US20100267132A1

  公开（公告）日：2010-10-21

  The invention is directed to compounds of Formula (I) or salts thereof. The invention is also directed to use of the compounds of formula (I) in the in vitro preservation of living animal cells. The living cells can be isolated cells, such as stem cells, or groups of cells such as tissue or an organ.