5-pyrazol-1-yl-thiazol-2-ylamine | 1314355-17-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-pyrazol-1-yl-thiazol-2-ylamine
• 英文别名: 5-(1H-Pyrazol-1-yl)-2-thiazolamine；5-pyrazol-1-yl-1,3-thiazol-2-amine
• CAS: 1314355-17-3
• 化学式: C₆H₆N₄S
• 分子量: 166.206
• InChiKey: ZRNZUBONIYOGJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  85
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND MEDICINAL APPLICATION
  申请人：Bhuniya Debnath

  公开号：US20100310493A1

  公开（公告）日：2010-12-09

  Acetamide derivatives, their stereoisomers, tautomers, prodrugs, pharmaceutically acceptable salts, polymorphs, solvates and formulations thereof for the prophylaxis, management, treatment, control of progression, or adjunct treatment of diseases and/or medical conditions where the activation of glucokinase would be beneficial, are disclosed. The disclosure also provides process of preparation of these acetamide derivatives.

  乙酰胺衍生物，它们的立体异构体、互变异构体、前药、药用可接受盐、多型体、溶剂合物及其配方，用于预防、管理、治疗、控制疾病和/或医疗状况的进展，或者作为激活葡萄糖激酶有益时的辅助治疗，已被披露。该披露还提供了这些乙酰胺衍生物的制备方法。
• [EN] BENZAMIDE COMPOUNDS AS GLUCOKINASE ACTIVATORS AND THEIR PHARMACEUTICAL APPLICATION<br/>[FR] COMPOSÉS DE BENZAMIDE À TITRE D'ACTIVATEURS DE GLUCOKINASE ET LEUR APPLICATION PHARMACEUTIQUE
  申请人：ADVINUS THERAPEUTICS PRIVATE LTD

  公开号：WO2011095997A1

  公开（公告）日：2011-08-11

  Benzamide compounds of formula (I), their stereoisomers, tautomers, prodrugs, pharmaceutically acceptable salts, polymorphs, solvates and formulations thereof useful as Glucokinase activators or modulators are disclosed. The disclosure further relates to process of preparation of the benzamide compounds.

  公开了化学式（I）的苯甲酰胺化合物，它们的立体异构体、互变异构体、前药、药用可接受的盐、多型体、溶剂合物和制剂，可用作葡萄糖激酶激活剂或调节剂。该公开还涉及苯甲酰胺化合物的制备过程。
• ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND MEDICINAL APPLICATIONS
  申请人：Bhuniya Debnath

  公开号：US20120214735A1

  公开（公告）日：2012-08-23

  Acetamide derivatives, their stereoisomers, tautomers, prodrugs, pharmaceutically acceptable salts, polymorphs, solvates and formulations thereof for the prophylaxis, management, treatment, control of progression, or adjunct treatment of diseases and/or medical conditions where the activation of glucokinase would be beneficial, are disclosed. The disclosure also provides process of preparation of these acetamide derivatives.

  本文披露了乙酰胺衍生物及其立体异构体、互变异构体、前药、药学上可接受的盐、多晶形、溶剂化物和制剂，用于预防、管理、治疗、控制进展或辅助治疗激活葡萄糖激酶有益的疾病和/或医疗条件。此外，本文还提供了制备这些乙酰胺衍生物的过程。
• Acetamide compounds as glucokinase activators, their process and medicinal applications
  申请人：Impetis Biosciences Ltd.

  公开号：EP2402327B1

  公开（公告）日：2018-03-07
• US8501955B2
  申请人：——

  公开号：US8501955B2

  公开（公告）日：2013-08-06