11-(2-methoxy-ethyl)-6,11-dihydro-5-thia-11-aza-benzo[α]fluorene-6-carboxylic acid diethylamide | 937185-95-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 11-(2-methoxy-ethyl)-6,11-dihydro-5-thia-11-aza-benzo[α]fluorene-6-carboxylic acid diethylamide
• 英文别名: 11-(2-Methoxy-ethyl)-6,11-dihydro-5-thia-11-aza-benzo[alpha]fluorene-6-carboxylic acid diethylamide；N,N-diethyl-11-(2-methoxyethyl)-6H-thiochromeno[4,3-b]indole-6-carboxamide
• CAS: 937185-95-0
• 化学式: C₂₃H₂₆N₂O₂S
• 分子量: 394.538
• InChiKey: KKICVFBGMKUFGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  59.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  11-(2-hydroxy-ethyl)-6,11-dihydro-5-thia-11-aza-benzo[α]fluorene-6-carboxylic acid diethylamide 、 碘甲烷 在 氢氧化钾 作用下， 以 二甲基亚砜 为溶剂， 反应 0.5h， 以55%的产率得到11-(2-methoxy-ethyl)-6,11-dihydro-5-thia-11-aza-benzo[α]fluorene-6-carboxylic acid diethylamide
  参考文献：
  名称：

  WO2007/57705

  摘要：

  公开号：

文献信息

• TETRACYCLIC INDOLE DERIVATIVES AS IN VIVO IMAGING AGENTS AND HAVING PERIPHERALBENZODIAZEPINE RECEPTOR AFFINITY (PBR)
  申请人：Arstad Erik

  公开号：US20090220420A1

  公开（公告）日：2009-09-03

  The present invention provides novel tetracyclic indole compounds of Formula (I) either as in vivo imaging agents or as therapeutic agents. A method for the preparation of the in vivo imaging agent compound is also provided by the invention, as well as a precursor for use in said method. Pharmaceutical compositions comprising the compounds of the invention are additionally provided. Where the pharmaceutical composition comprises a compound suitable for in vivo imaging, a kit is provided for the preparation of the pharmaceutical composition. In a further aspect, use of the compound for in vivo imaging or treatment of conditions associated with PBR is provided.

  本发明提供了新型四环吲哚化合物（I）作为体内成像剂或治疗剂。本发明还提供了一种用于制备体内成像剂化合物的方法，以及用于该方法的前体。此外，还提供了包含本发明化合物的制药组合物。其中，如果制药组合物包含适用于体内成像的化合物，则提供用于制备制药组合物的工具包。在另一个方面，提供了将该化合物用于体内成像或治疗与PBR相关病症的用途。
• Tetracyclic indole derivatives as in vivo imaging agents and having peripheralbenzodiazepine receptor affinity (PBR)
  申请人：Arstad Erik

  公开号：US08506932B2

  公开（公告）日：2013-08-13

  The present invention provides novel tetracyclic indole compounds of Formula (I) either as in vivo imaging agents or as therapeutic agents. A method for the preparation of the in vivo imaging agent compound is also provided by the invention, as well as a precursor for use in said method. Pharmaceutical compositions comprising the compounds of the invention are additionally provided. Where the pharmaceutical composition comprises a compound suitable for in vivo imaging, a kit is provided for the preparation of the pharmaceutical composition. In a further aspect, use of the compound for in vivo imaging or treatment of conditions associated with PBR is provided.

  本发明提供了新型四环吲哚化合物（式（I）），可作为体内成像试剂或治疗剂。本发明还提供了一种制备体内成像试剂化合物的方法，以及用于该方法的前体。此外，本发明还提供了包括本发明化合物的药物组合物。如果药物组合物包括适用于体内成像的化合物，则提供用于制备药物组合物的试剂盒。在另一方面，本发明提供了将该化合物用于体内成像或治疗与PBR相关疾病的方法。
• US8506932B2
  申请人：——

  公开号：US8506932B2

  公开（公告）日：2013-08-13
• [EN] TETRACYCLIC INDOLE DERIVATIVES AS IN VIVO IMAGING AGENTS AND HAVING PERIPHERALBENZODIAZEPINE RECEPTOR AFFINITY (PBR)<br/>[FR] DERIVES D'INDOLE TETRACYCLIQUE EN TANT QU'AGENTS DE FORMATION D'IMAGES IN VIVO ET AYANT UNE AFFINITE POUR LES RECEPTEURS DE PERIPHERALBENZODIAZEPINE
  申请人：HAMMERSMITH IMANET LTD

  公开号：WO2007057705A1

  公开（公告）日：2007-05-24

  [EN] The present invention provides novel tetracyclic indole compounds of Formula (I) either as in vivo imaging agents or as therapeutic agents. A method for the preparation of the in vivo imaging agent compound is also provided by the invention, as well as a precursor for use in said method. Pharmaceutical compositions comprising the compounds of the invention are additionally provided. Where the pharmaceutical composition comprises a compound suitable for in vivo imaging, a kit is provided for the preparation of the pharmaceutical composition. In a further aspect, use of the compound for in vivo imaging or treatment of conditions associated with PBR is provided.
  [FR] La présente invention concerne de nouveaux composés d'indole tétracyclique de formule (I), soit en tant qu'agents de formation d'images in vivo, soit en tant qu'agents thérapeutiques. L'invention concerne également un procédé de fabrication dudit agent de formation d'images in vivo, ainsi qu'un précurseur destiné être utilisé dans ledit procédé. L'invention concerne en outre des compositions pharmaceutiques comprenant les composés selon l'invention. L'invention concerne un kit pour la préparation de la composition pharmaceutique, lorsque la composition pharmaceutique comprend un composé adapté pour la formation d'images in vivo. L'invention concerne selon un autre aspect l'utilisation du composé pour la formation d'images in vivo ou le traitement de troubles associés aux récepteurs de périphéralbenzodiazépine.
• WO2007/57705
  申请人：——

  公开号：——

  公开（公告）日：——