<2-oxo-6-(aminomethyl)morpholyl>-N,N',N'-triacetic acid triethyl ester | 175916-39-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: <2-oxo-6-(aminomethyl)morpholyl>-N,N',N'-triacetic acid triethyl ester
• CAS: 175916-39-9
• 化学式: C₁₇H₂₈N₂O₈
• 分子量: 388.418
• InChiKey: WVCYZVAJZRLTCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.79
• 重原子数：
  27.0
• 可旋转键数：
  11.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  111.68
• 氢给体数：
  0.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  <2-oxo-6-(aminomethyl)morpholyl>-N,N',N'-triacetic acid triethyl ester 在 硼烷四氢呋喃络合物 作用下， 以 甲醇 为溶剂， 反应 288.0h， 生成 26-hydroxy-1,4,7,10,13,16,19,22-octaazabicyclo[11.11.3]heptacosane
  参考文献：
  名称：

  Novel Properties of Cooperative Dinuclear Zinc(II) Ions:  The Selective Recognition of Phosphomonoesters and Their P−O Ester Bond Cleavage by a New Dinuclear Zinc(II) Cryptate

  摘要：

  A propanol-bridged octaazacryptand (26-hydroxy-1,4,7,10,13,16,19,22-octaazabicyclo [11.11.3]heptacosane, HL) has been synthesized from diethylenetriamine and [2-oxo-6-(aminomethyl)morpholyl]-N,N',N'-triacetic acid triethyl ester by refluxing in MeOH followed by BH3 . THF reduction. This octaazacryptand forms a novel dinuclear zinc(II) cryptate (Zn(2)L) (L = alkoxide form of HL) in aqueous solution. The X-ray crystal structure of the cryptate showed each zinc(II) ion in a distorted trigonal-bipyramidal environment involving two NH's and an alkoxide O- anion as equatorial donors, with tertiary amine and an NH stand in apical positions. Crystals of the triperchlorate salt of Zn(2)L (C19H43N8O13Cl3Zn2) are monoclinic, space group P2(1)/n (No. 14) with a = 15.037(5) Angstrom, b = 13.862(5) Angstrom, c = 15.780(4) Angstrom, beta = 90.29(2)degrees, Z = 4, and R = 0.109. Although the two zinc(II) ions (separated with a distance of 3.42 Angstrom) in the cryptate appeared to be coordinately saturated and hence were assumed unreactive, they work together to selectively interact with a phosphomonoester, 4-nitrophenyl phosphate dianion (NPP2-), and promote the cleavage of its P-O ester bond by nucleophilic attack of one of the apically coordinated NH's at pH 4.9-9.5 in aqueous solution. The reaction product was isolated as a phosphoramide derivative (Zn(2)L-PO3H) from aqueous solution at pH 3 and characterized by X-ray crystal analysis. Crystals of Zn(2)L-PO3H . 2H(2)O .(ClO4)(3)(C19H48N8O18Cl3Zn2) are monoclinic, space group Cc (No. 9) with a = 19.573(3) Angstrom, b = 12.454(4) Angstrom, c = 15.066(3) Angstrom, beta = 103.94(1)degrees, Z = 4, and R = 0.036. The structure of Zn(2)L-PO3H featured the two phosphoryl oxygens bound to each zinc(II) ion in place of the original two apical NH's. The kinetics were followed for liberation of 4-nitrophenol (the maximum second-order rate constant k(NPP) = (1.52 +/- 0.05) x 10(-3) M(-1) s(-1) at pH 5.9 and 35 degrees C). The rate vs pH profile with 5 mM Zn(2)L and 10 mM 4-nitrophenyl phosphate showed a bell-shaped curve with pK(2) of 5.2 and pK(2) of 6.3, which were assigned to the protonation constants for NPP2- + H reversible arrow HNPP- and NH (a freed apical donor in the associated reaction intermediate) + H+ reversible arrow HNH+, respectively. The most remarkable character of the present new zinc(II) cryptate was that it reacted only with phosphoester polyanions such as NPP2- and ATP(4-), but not with bis(4- nitrophenyl) phosphodiester monoanion, tris(4-nitrophenyl phosphotriester, or 4-nitrophenyl acetate. The present results may well be relevant to the significance of dinuclear metal centers in metallophosphatases such as alkaline monophosphatase.

  DOI：

  10.1021/ja953413m
• 作为产物：
  描述：

  1,3-二氨基-2-丙醇-N,N,N,N-四乙酸 、 乙醇 在 氯化亚砜 作用下， 反应 24.0h， 以58%的产率得到<2-oxo-6-(aminomethyl)morpholyl>-N,N',N'-triacetic acid triethyl ester
  参考文献：
  名称：

  Novel Properties of Cooperative Dinuclear Zinc(II) Ions:  The Selective Recognition of Phosphomonoesters and Their P−O Ester Bond Cleavage by a New Dinuclear Zinc(II) Cryptate

  摘要：

  A propanol-bridged octaazacryptand (26-hydroxy-1,4,7,10,13,16,19,22-octaazabicyclo [11.11.3]heptacosane, HL) has been synthesized from diethylenetriamine and [2-oxo-6-(aminomethyl)morpholyl]-N,N',N'-triacetic acid triethyl ester by refluxing in MeOH followed by BH3 . THF reduction. This octaazacryptand forms a novel dinuclear zinc(II) cryptate (Zn(2)L) (L = alkoxide form of HL) in aqueous solution. The X-ray crystal structure of the cryptate showed each zinc(II) ion in a distorted trigonal-bipyramidal environment involving two NH's and an alkoxide O- anion as equatorial donors, with tertiary amine and an NH stand in apical positions. Crystals of the triperchlorate salt of Zn(2)L (C19H43N8O13Cl3Zn2) are monoclinic, space group P2(1)/n (No. 14) with a = 15.037(5) Angstrom, b = 13.862(5) Angstrom, c = 15.780(4) Angstrom, beta = 90.29(2)degrees, Z = 4, and R = 0.109. Although the two zinc(II) ions (separated with a distance of 3.42 Angstrom) in the cryptate appeared to be coordinately saturated and hence were assumed unreactive, they work together to selectively interact with a phosphomonoester, 4-nitrophenyl phosphate dianion (NPP2-), and promote the cleavage of its P-O ester bond by nucleophilic attack of one of the apically coordinated NH's at pH 4.9-9.5 in aqueous solution. The reaction product was isolated as a phosphoramide derivative (Zn(2)L-PO3H) from aqueous solution at pH 3 and characterized by X-ray crystal analysis. Crystals of Zn(2)L-PO3H . 2H(2)O .(ClO4)(3)(C19H48N8O18Cl3Zn2) are monoclinic, space group Cc (No. 9) with a = 19.573(3) Angstrom, b = 12.454(4) Angstrom, c = 15.066(3) Angstrom, beta = 103.94(1)degrees, Z = 4, and R = 0.036. The structure of Zn(2)L-PO3H featured the two phosphoryl oxygens bound to each zinc(II) ion in place of the original two apical NH's. The kinetics were followed for liberation of 4-nitrophenol (the maximum second-order rate constant k(NPP) = (1.52 +/- 0.05) x 10(-3) M(-1) s(-1) at pH 5.9 and 35 degrees C). The rate vs pH profile with 5 mM Zn(2)L and 10 mM 4-nitrophenyl phosphate showed a bell-shaped curve with pK(2) of 5.2 and pK(2) of 6.3, which were assigned to the protonation constants for NPP2- + H reversible arrow HNPP- and NH (a freed apical donor in the associated reaction intermediate) + H+ reversible arrow HNH+, respectively. The most remarkable character of the present new zinc(II) cryptate was that it reacted only with phosphoester polyanions such as NPP2- and ATP(4-), but not with bis(4- nitrophenyl) phosphodiester monoanion, tris(4-nitrophenyl phosphotriester, or 4-nitrophenyl acetate. The present results may well be relevant to the significance of dinuclear metal centers in metallophosphatases such as alkaline monophosphatase.

  DOI：

  10.1021/ja953413m