(E)-N'-(((4bS,8aR,9R)-4b-methoxy-7-oxo-4b,7,8,8a,9,10-hexahydrophenanthrene-9-yl)methylene)benzenesulfonylhydrazide | 1005008-21-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: (E)-N'-(((4bS,8aR,9R)-4b-methoxy-7-oxo-4b,7,8,8a,9,10-hexahydrophenanthrene-9-yl)methylene)benzenesulfonylhydrazide
• 英文别名: N-[(E)-[(4bR,8aS,9S)-4b-methoxy-7-oxo-8,8a,9,10-tetrahydrophenanthren-9-yl]methylideneamino]benzenesulfonamide
• CAS: 1005008-21-8
• 化学式: C₂₂H₂₂N₂O₄S
• 分子量: 410.494
• InChiKey: DYYGVUCYJVVWBZ-VKXLVQFQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  93.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (4bR,8aS,9S)-4b-methoxy-7-oxo-4b,7,8,8a,9,10-hexahydrophenanthrene-9-carbaldehyde 、 苯磺酰肼 以 二氯甲烷 为溶剂， 反应 0.25h， 以99%的产率得到(E)-N'-(((4bS,8aR,9R)-4b-methoxy-7-oxo-4b,7,8,8a,9,10-hexahydrophenanthrene-9-yl)methylene)benzenesulfonylhydrazide
  参考文献：
  名称：

  An Enantioselective Organocatalytic Oxidative Dearomatization Strategy

  摘要：

  We have developed a catalytic enantioselective strategy for chemical synthesis wherein flat aromatic molecules are directly converted to complex nonremmic molecular arch lectures. The process Involves oxidative dearomatization of substituted phenols followed by a desymmebrizing secondry amine-catalyzed asymmetric intermolecular Michael addition and reveals a declin structure formed with exquisite control of three now streogenic centers and an array of exploitable orthogonal functionality directly from a flat molecule that is devoid or architectural complexity.

  DOI：

  10.1021/ja077457u