diethyl-{2-[3-(1-methyl-1H-pyrazol-4-yl)-phenyl]-ethyl}-amine | 1034142-49-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: diethyl-{2-[3-(1-methyl-1H-pyrazol-4-yl)-phenyl]-ethyl}-amine
• 英文别名: N,N-diethyl-2-[3-(1-methylpyrazol-4-yl)phenyl]ethanamine
• CAS: 1034142-49-8
• 化学式: C₁₆H₂₃N₃
• 分子量: 257.379
• InChiKey: ONJNBXMSAGVOTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  21.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Combination of a 5-HT7 receptor ligand and an opioid receptor ligand
  申请人：Laboratorios del Dr. Esteve S.A.

  公开号：EP1997493A1

  公开（公告）日：2008-12-03

  The present invention refers to a combination of a 5HT7 receptor ligand and an opioid recptor ligand, especially of a 5HT7 receptor agonist and an opioid recptor agonist, a medicament comprising this combination, or the use of this combination for the treatment of the symptoms of pain, the prevention or the prophylaxis of the symptoms of pain.

  本发明涉及一种5HT7受体配体和阿片受体配体的组合，特别是一种5HT7受体激动剂和阿片受体激动剂，包含该组合的药物，或者利用该组合治疗疼痛症状，预防或预防疼痛症状的用途。
• Heterocyclyl-substituted-ethylamino-phenyl derivatives, their preparation and use as medicaments
  申请人：Laboratorios del Dr. Esteve S.A.

  公开号：EP1935886A1

  公开（公告）日：2008-06-25

  The present invention relates to heterocyclyl-substituted-ethylamino-phenyl compounds of general formula (I) wherein K-L-M-N, Z and R1, R2, R3, R4 are described in the claims, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatments of humans or animals.

  本发明涉及一般式（I）的杂环取代乙基氨基苯化合物，其中K-L-M-N，Z和R1，R2，R3，R4在权利要求书中描述，其制备方法，包括这些化合物的药物以及它们用于制备用于治疗人类或动物的药物的用途。
• COMBINATION OF A 5HT7 RECEPTOR LIGAND AND AN OPIOID RECEPTOR LIGAND
  申请人：Romero-Alonso Luz

  公开号：US20100197717A1

  公开（公告）日：2010-08-05

  The present invention refers to a combination of a 5HT7 receptor ligand and an opioid receptor ligand, especially of a 5HT7 receptor agonist and an opioid receptor agonist, a medicament comprising this combination, or the use of this combination for the treatment of the symptoms of pain, the prevention or the prophylaxis of the symptoms of pain.

  本发明涉及一种5HT7受体配体和阿片受体配体的组合，特别是5HT7受体激动剂和阿片受体激动剂的组合，包括此组合的药物，或者使用此组合治疗疼痛症状、预防或预防疼痛症状。
• Heterocyclyl-substituted-phenyl derivatives as vasodilators
  申请人：Laboratorios del Dr. Esteve S.A.

  公开号：EP2676954A1

  公开（公告）日：2013-12-25

  The present invention relates to heterocyclyl-substituted-phenyl compounds of general formula (I), for use as vasodilator agents and the pharmaceutical compositions comprising them. wherein A is a compound selected from the following group: n is selected from 0 or 1.

  本发明涉及通式（I）的杂环取代苯基化合物，可用作血管扩张剂和由其组成的药物组合物。 其中 A 是选自下组的化合物： n 选自 0 或 1。
• HETEROCYCLYL-SUBSTITUTED-EHYLAMINO-PHENYL DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP2114894A1

  公开（公告）日：2009-11-11