| 1437802-95-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异香豆素
• CAS: 1437802-95-3
• 化学式: C₂₁H₁₀Cl₄O₂
• 分子量: 436.121
• InChiKey: OGMSHJRRIRRSFJ-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 盐酸羟胺 、 sodium acetate 作用下， 以 乙醇 、 水 为溶剂， 反应 1.0h， 生成 4-[bis-(3’,4’-dichloro-phenyl)methyl]-benzo[d][1,2]oxazin-1-one
  参考文献：
  名称：

  Synthesis of biologically important phthalazinones, 2,3-benzoxazin-1-ones and isoindolinones from ninhydrin and their antimicrobial activity

  摘要：

  Biologically important phthalazinones, 2,3-benzoxazin-1-ones and isoindolinones have been synthesized from easily available ninhydrin in good yields. The appropriate ninhydrin adducts 2,2,-diaryl-1,3-indanediones and 3-(diarylmethylene)isobenzofuranones were treated with various nucleophiles like hydrazine hydrate, hydroxylamine, and phenylhydrazin to accomplish the heterocycles. The synthesized compounds were assayed for their antibacterial activity and showed significant activity against both the selected Gram positive and Gram negative bacteria, suggesting possible scope of using as antimicrobials. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.04.015