4'-甲氧基联苯基-2-甲酰胺 | 39950-00-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4'-甲氧基联苯基-2-甲酰胺
• 英文名称: 4'-methoxybiphenyl-2-carboxamide
• 英文别名: 4'-methoxy-biphenyl-2-carboxylic acid amide；4'-Methoxy-biphenyl-2-carbonsaeure-amid；4'-Methoxy-[1,1'-biphenyl]-2-carboxamide；2-(4-methoxyphenyl)benzamide
• CAS: 39950-00-0
• 化学式: C₁₄H₁₃NO₂
• 分子量: 227.263
• InChiKey: OGRYGSBBZDPBTH-UHFFFAOYSA-N

物化性质

• 熔点：
  114-115 °C(Solv: water (7732-18-5); ethanol (64-17-5))
• 沸点：
  412.1±38.0 °C(Predicted)
• 密度：
  1.151±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4'-甲氧基联苯基-2-甲酰胺 在 盐酸 、 锂硼氢 、 phosphorus pentoxide 、 氢气 、 sodium hydride 、 sodium cyanoborohydride 、 三乙胺 作用下， 以 二氯甲烷 、 溶剂黄146 、 甲苯 为溶剂， 反应 5.33h， 生成 5-(4-Methoxy-phenyl)-1,4-dihydro-2H-isoquinoline-3,3-dicarboxylic acid diethyl ester
  参考文献：
  名称：

  A novel series of selective, non-peptide inhibitors of angiotensin II binding to the AT2 site

  摘要：

  The availability of peptide and non-peptide Ang II receptor antagonists has permitted the study of Ang II receptor heterogeneity. It is now widely recognized that there are at least two distinct Ang II receptor subtypes. AT(1) receptors are selective in their recognition of agents such as losartan, DuP 532, L-158,809, SK&F108566, and similar non-peptides. To date, all of the well-known actions of Ang II in mammals are blocked by the AT(1) selective antagonists such as losartan and are thus designated as being mediated by the AT(1) receptor. Although there have been reports of functional activity mediated through AT(2) sites, the pharmacological role for the AT(2) receptor has not yet been elucidated. Herein, we report the chemistry and SAR on a novel series of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids which have selective affinity for AT(2) receptors. The most potent of which (19) has an IC50 Of 30 nM for the AT(2) receptor in the rat adrenal radioligand binding assay.

  DOI：

  10.1021/jm00077a001
• 作为产物：
  描述：

  2-(2-甲氧基苯基)-4,4-二甲基-2-噁唑啉 在 硫酸 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 4.0h， 生成 4'-甲氧基联苯基-2-甲酰胺
  参考文献：
  名称：

  A novel series of selective, non-peptide inhibitors of angiotensin II binding to the AT2 site

  摘要：

  The availability of peptide and non-peptide Ang II receptor antagonists has permitted the study of Ang II receptor heterogeneity. It is now widely recognized that there are at least two distinct Ang II receptor subtypes. AT(1) receptors are selective in their recognition of agents such as losartan, DuP 532, L-158,809, SK&F108566, and similar non-peptides. To date, all of the well-known actions of Ang II in mammals are blocked by the AT(1) selective antagonists such as losartan and are thus designated as being mediated by the AT(1) receptor. Although there have been reports of functional activity mediated through AT(2) sites, the pharmacological role for the AT(2) receptor has not yet been elucidated. Herein, we report the chemistry and SAR on a novel series of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids which have selective affinity for AT(2) receptors. The most potent of which (19) has an IC50 Of 30 nM for the AT(2) receptor in the rat adrenal radioligand binding assay.

  DOI：

  10.1021/jm00077a001

文献信息

• [EN] FUNCTIONALISED AND SUBSTITUTED INDOLES AS ANTI-CANCER AGENTS<br/>[FR] INDOLES FONCTIONNALISÉS ET SUBSTITUÉS UTILISÉS EN TANT QU'AGENTS ANTI-CANCÉREUX
  申请人：NOVOGEN LTD

  公开号：WO2015074123A1

  公开（公告）日：2015-05-28

  The present invention relates to anti-tropomyosin compounds, processes for their preparation, and methods for treating or preventing a proliferative disease, preferably cancer, using compounds of the invention.

  本发明涉及抗肌球蛋白化合物，其制备方法，以及利用本发明的化合物治疗或预防增殖性疾病，优选癌症的方法。
• An organic cation as a silver(<scp>i</scp>) analogue for the arylation of sp² and sp³ C–H bonds with iodoarenes
  作者：Carlos Arroniz、J. Gabriel Denis、Alan Ironmonger、Gerasimos Rassias、Igor Larrosa

  DOI：10.1039/c4sc01215a

  日期：——

  A general, cost-effective and sustainable replacement for silver in palladium catalysed direct arylations of C(sp²)–H and C(sp³)–H bonds.

  一种通用、具有成本效益且可持续的替代品，用于钯催化的直接芳基化反应中取代银在C(sp²)-H和C(sp³)-H键中的作用。
• [EN] 1,2-BENZISOSELENAZOL-3(2H)-ONE AND 1,2-BENZISOTHIAZOL-3(2H)-ONE DERIVATIVES AS BETA-LACTAM ANTIBIOTIC ADJUVANTS<br/>[FR] DÉRIVÉS DE 1,2-BENZISOSÉLÉNAZOL-3(2H)-ONE ET DE 1,2-BENZISOTHIAZOL-3(2H)-ONE UTILISÉS COMME ADJUVANTS D'ANTIBIOTIQUES BÊTA-LACTAME
  申请人：UNIV HONG KONG POLYTECHNIC

  公开号：WO2019174279A1

  公开（公告）日：2019-09-19

  Provided herein are compositions and methods useful in the treatment of beta-lactam antibiotic resistant bacteria.

  本文提供了在治疗β-内酰胺类抗生素耐药细菌方面有用的组合物和方法。
• Multiple Cross-Coupling Reactions of Aryl and Benzylic Zinc Halides with Aryl Halides and Triflates in Solid-Phase Synthesis of Polyfunctional Aromatics
  作者：Mario Rottländer、Paul Knochel

  DOI：10.1055/s-1997-1529

  日期：1997.9

  Aryl and benzylic zinc bromides undergo efficient Pd(0)-catalyzed cross-coupling reactions on the solid-phase using either Rink or Wang resin. By performing the cross-couplings with the multi-coupling reagents 2 and 3 two successive carbon-carbon bond forming reactions are possible on the solid-phase.

  使用 Rink 或 Wang 树脂，芳基和苄基溴化锌在固相上进行高效的 Pd(0)- 催化交叉偶联反应。通过与多元偶联试剂 2 和 3 发生交叉偶联反应，可以在固相上连续进行两个碳-碳键形成反应。
• ESTROGEN RECEPTOR LIGANDS AND METHODS OF USE THEREOF
  申请人：GTx, Inc.

  公开号：US20160031797A1

  公开（公告）日：2016-02-04

  The present invention relates to a novel class of nuclear receptor binding agents (NRBAs). The NRBA compounds are applicable for use in the prevention and/or treatment of a variety of diseases and conditions including, inter alia, prevention and treatment of hormone-related diseases, cancers, inflammation, osteoporosis, peripheral vascular disease, reducing circulating lipid levels, and cardiovascular disease.

  本发明涉及一种新型的核受体结合剂（NRBAs）。NRBA化合物可用于预防和/或治疗各种疾病和病症，包括但不限于预防和治疗激素相关疾病、癌症、炎症、骨质疏松症、外周血管疾病、降低循环脂质水平和心血管疾病。