Concentrated, low-viscosity, low-volume liquid pharmaceutical formulations of proteins have been developed. Such formulations can be rapidly and conveniently administered by subcutaneous or intramuscular injection, rather than by lengthy intravenous infusion. These formulations include low-molecular-weight and/or high-molecular-weight proteins, such as mAbs, and viscosity-reducing ionic liquids.
目前已开发出浓缩、低粘度、低容量的液体蛋白质药物制剂。这些制剂可以通过皮下注射或肌肉注射快速方便地给药,而不需要长时间的静脉注射。这些制剂包括低分子量和/或高分子量蛋白质(如 mAbs)以及降粘
离子液体。