{4-methoxy-3-[4-(1-methyl-1H-pyrazol-4-yl)-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-phenyl}-acetic acid ethyl ester | 1182353-03-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: {4-methoxy-3-[4-(1-methyl-1H-pyrazol-4-yl)-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-phenyl}-acetic acid ethyl ester
• 英文别名: ethyl 2-[4-methoxy-3-[4-(1-methylpyrazol-4-yl)-2-[(2-oxo-1,3-oxazolidin-3-yl)methyl]phenoxy]phenyl]acetate
• CAS: 1182353-03-2
• 化学式: C₂₅H₂₇N₃O₆
• 分子量: 465.506
• InChiKey: MMEIKKQXWYKGRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  34
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  92.1
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  {3-[4-bromo-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-4-methoxy-phenyl}-acetic acid ethyl ester 、 1-甲基-4-(4,4,5,5-四甲基-1,3,2-二氧杂戊硼烷-2-基)-1H-吡唑 生成 {4-methoxy-3-[4-(1-methyl-1H-pyrazol-4-yl)-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-phenyl}-acetic acid ethyl ester
  参考文献：
  名称：

  CYCLIC DIARYL ETHER COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS

  摘要：

  本文描述了PGD2受体拮抗剂化合物。还描述了包括本文所述的PGD2受体拮抗剂在内的制药组合物和药物，以及使用这种PGD2受体拮抗剂，单独或与其他化合物结合，治疗呼吸系统、心血管系统和其他PGD2依赖性或PGD2介导的疾病或病症的方法。

  公开号：

  US20110098302A1

文献信息

• Cyclic diaryl ether compounds as antagonists of prostaglandin D2 receptors
  申请人：Panmira Pharmaceuticals, LLC

  公开号：US08242145B2

  公开（公告）日：2012-08-14

  Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the antagonists of PGD2 receptors described herein, as well as methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.

  本文介绍了PGD2受体拮抗剂化合物。还介绍了包括这些PGD2受体拮抗剂在内的制药组合物和药物，以及使用这些PGD2受体拮抗剂的方法，单独或与其他化合物结合，用于治疗呼吸系统、心血管系统和其他依赖或介导PGD2的疾病或病症。
• US8242145B2
  申请人：——

  公开号：US8242145B2

  公开（公告）日：2012-08-14
• [EN] CYCLIC DIARYL ETHER COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 receptors<br/>[FR] COMPOSÉS DIARYLIQUES CYCLIQUES EN TANT QU'ANTAGONISTES DE RÉCEPTEURS DE PROSTAGLANDINE D2
  申请人：AMIRA PHARMACEUTICALS INC

  公开号：WO2009102893A2

  公开（公告）日：2009-08-20

  Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the antagonists of PGD2 receptors described herein, as well as methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.