pyrrole-2-carboxaldehyde [4-(4-fluorophenyl)-1,3-thiazol-2-yl]hydrazone | 1447734-92-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: pyrrole-2-carboxaldehyde [4-(4-fluorophenyl)-1,3-thiazol-2-yl]hydrazone
• CAS: 1447734-92-0
• 化学式: C₁₄H₁₁FN₄S
• 分子量: 286.333
• InChiKey: YDOXHFRDWYYKAI-UHFFFAOYSA-N

物化性质

• 熔点：
  166 °C
• 沸点：
  504.6±53.0 °C(predicted)
• 密度：
  1.37±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.72
• 重原子数：
  20.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  53.07
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  2-吡咯甲醛 以 乙醇 为溶剂， 反应 2.0h， 生成 pyrrole-2-carboxaldehyde [4-(4-fluorophenyl)-1,3-thiazol-2-yl]hydrazone
  参考文献：
  名称：

  Synthesis and antimicrobial activity of some new hydrazone-bridged thiazole-pyrrole derivatives

  摘要：

  In this work, we synthesized fourteen different compounds which contain hydrazone bridged thiazole and pyrrole rings. For this purpose, pyrrole-2-carboxaldehydes were reacted directly with thiosemicarbazide in ethanol and then obtained thiosemicarbazones were condensed with alpha-bromoacetophenone derivatives (Hantzsch reaction) to give 1-substituted pyrrole-2-carboxaldehyde [4-(4-substituted phenyl)-1,3-thiazol-2-yl] hydrazones. The structures of the obtained compounds were elucidated by using IR, H-1-NMR and FAB(+)-MS spectral data and elemental analyses results. All of the compounds were screened for their antibacterial and antifungal activities against twelve different microorganisms by using microbroth dilution method. Ketoconazole and chloramphenicol were used as standard drugs. All of the compounds showed good activity against Staphylococcus aureus and Enterococcus faecalis.

  DOI：

  10.3109/14756366.2012.688043