[4-(4-methylsulfonylphenyl)-5-phenyl]-2-oxazoleacetic acid | 163304-10-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [4-(4-methylsulfonylphenyl)-5-phenyl]-2-oxazoleacetic acid
• 英文别名: 2-(carboxymethyl)-4-(4-methylsulfonylphenyl)-5-phenyloxazole；2-[4-(4-Methylsulfonylphenyl)-5-phenyl-1,3-oxazol-2-yl]acetic acid
• CAS: 163304-10-7
• 化学式: C₁₈H₁₅NO₅S
• 分子量: 357.387
• InChiKey: ZQNGJCNGGROTDY-UHFFFAOYSA-N

物化性质

• 沸点：
  580.6±50.0 °C(Predicted)
• 密度：
  1.347±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  106
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Oxaprozin or closely related compound for the treatment and prevention of pruritus
  申请人：Astion Development A/S

  公开号：EP1707199A1

  公开（公告）日：2006-10-04

  The invention provides methods and medicaments for the treatment of pruritus in general or pruritus caused by or associated with dermatological diseases including the treatment of the underlying disease by topically administering to skin or by systemically administering to a subject Oxaprozin or a closely related compound or a salt thereof.

  本发明提供了治疗瘙痒症的方法和药物，包括治疗与皮肤病相关的瘙痒症，通过局部给药或全身给药氧氯氮或其密切相关化合物或其盐来治疗基础疾病。
• [EN] SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION<br/>[FR] OXAZOLES SUBSTITUES UTILISES DANS LE TRAITEMENT D'INFLAMMATIONS
  申请人：G.D. SEARLE & CO.

  公开号：WO1996036617A1

  公开（公告）日：1996-11-21

  (EN) A class of substituted oxazoles is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by formula (I), wherein R is selected from hydrido, halo, mercapto, hydroxyl, carboxyalkylthio, carboxyalkylthioalkyl, carboxyalkoxy, carboxyalkoxyalkyl, haloalkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkoxy, aryloxy, aralkoxy, alkylamino, aminocarbonyl, alkoxyalkyl, carboxy(haloalkyl), alkyl, hydroxyalkyl, haloalkyl, alkenyl, hydroxyalkenyl, alkynyl, hydroxyalkynyl, cycloalkyl, cycloalkylalkyl, aminoalkyl, hydroxyalkoxyalkyl, alkylcarbonyl, phosphonylalkyl, amino acid residue, heterocyclylalkyl, cyanoalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, carboxy, carboxyalkyl, arylthioalkyl, aminocarbonylalkyl, alkylcarbonylaminoalkyl, alkoxycarbonylaminoalkyl, aralkoxycarbonylaminoalkyl, aryl, heteroaryl, aralkyl, aryloxyalkyl, aralkoxyalkyl, heteroaryloxyalkyl and heteroarylalkoxyalkyl; wherein R1 is selected from cycloalkyl, cycloalkenyl, aryl and heterocyclyl, wherein R1 is optionally substituted at a substitutable position by alkyl, alkylamino, alkoxy and halo; wherein R2 is selected from alkyl and amino; and wherein R3 is selected from hydrido and alkyl.(FR) L'invention se rapporte à une classe d'oxazoles substitués destinés à être utilisés dans le traitement d'inflammations ou de troubles liés à des inflammations. Des composés d'intérêt particulier sont définis par la formule (I) dans laquelle R est sélectionné parmi hydrido, halo, mercapto, hydroxyle, carboxyalkylthio, carboxyalkylthioalkyle, carboxyalcoxy, carboxyalcoxyalkyle, haloalcoxy, alkylthio, alkylsulfinyle, alkylsulfonyle, alcoxy, aryloxy, aralcoxy, alkylamino, aminocarbonyle, alcoxyalkyle, carboxy(haloalkyle), alkyle, hydroxyalkyle, haloalkyle, alcényle, hydroxyalcényle, alkynyle, hydroxyalkynyle, cycloalkyle, cycloalkylalkyle, aminoalkyle, hydroxyalcoxyalkyle, alkylcarbonyle, phosphonylalkyle, un résidu aminoacide, hétérocyclylalkyle, cyanoalkyle, alcoxycarbonyle, alcoxycarbonylalkyle, carboxy, carboxyalkyle, arylthioalkyle, aminocarbonylalkyle, alkylcarbonylaminoalkyle, alcoxycarbonylaminoalkyle, aralcoxycarbonylaminoalkyle, aryle, hétéroaryle, aralkyle, aryloxyalkyle, aralcoxyalkyle, hétéroaryloxyalkyle et hétéroarylalcoxyalkyle; où R1 est sélectionné parmi cycloalkyle, cycloalcényle, aryle et hétérocyclyle, R1 étant éventuellement substitué à une position substituable par alkyle, alkylamino, alcoxy et halo; où R2 est sélectionné parmi alkyle et amino; et où R3 est sélectionné parmi hydrido et alkyle.

  (中文) 描述了一类替代噁唑用于治疗炎症和与炎症相关的疾病。特别感兴趣的化合物由公式（I）定义，其中R从氢化物，卤素，巯基，羟基，羧基烷基硫，羧基烷基硫烷基，羧基烷氧基，羧基烷氧基烷基，卤代烷氧基，烷基硫，烷基亚磺酰基，烷氧基，芳氧基，芳基氧烷基，烷基氨基，氨基羰基，烷氧基烷基，羧基（卤代烷基），烷基，羟基烷基，卤代烷基，烯基，羟基烯基，炔基，羟基炔基，环烷基，环烷基烷基，氨基烷基，羟基烷氧基烷基，烷基羰基，磷酸酯基烷基，氨基酸残基，杂环烷基烷基，氰基烷基，烷氧羰基，烷氧羰基烷基，羧基，羧基烷基，芳基硫烷基，氨基羰基烷基，烷基羰基氨基烷基，烷氧羰基氨基烷基，芳基氧羰基氨基烷基，芳基，杂环芳基，芳基氧烷基，芳基氧烷基烷基，杂环芳基氧烷基和杂环芳基氧烷基烷基中选择; 其中R1从环烷基，环烯基，芳基和杂环烷基中选择，其中R1在可替换位置上可选地被烷基，烷基氨基，烷氧基和卤素取代; 其中R2从烷基和氨基中选择; 而R3从氢化物和烷基中选择。
• Dermatological compositions comprising oxaprozin or a closely related compound for the treatment of dermatological diseases
  申请人：Astion Development A/S

  公开号：EP1707200A1

  公开（公告）日：2006-10-04

  The invention relates to dermatological compositions of Oxaprozin or a closely related compound suitable adapted for the treatment of a dermatological disease, where at least two of the enzymes selected from protein tyrosine kinase Syk, protein tyrosine kinase ZAP-70 and phosphodiesterase IV play a role in mediating the dermatological disease. The invention also encompasses dermatological compositions for the treatment of pruritus.

  本发明涉及奥沙普秦或密切相关化合物的皮肤病组合物，适用于治疗皮肤病，其中至少两种酶选自蛋白酪氨酸激酶Syk、蛋白酪氨酸激酶ZAP-70和磷酸二酯酶IV，它们在介导皮肤病中发挥作用。本发明还包括用于治疗瘙痒症的皮肤病组合物。
• Oxaprozin or a closely related compound for the treatment of eczema
  申请人：Astion Development A/S

  公开号：EP1707201A1

  公开（公告）日：2006-10-04

  The present invention relates to a novel principle of treating dermatological diseases comprising inhibiting several crucial steps in the inflammatory cascade including at least the inhibition of one or more of the enzymes Protein tyrosine kinase Syk, Protein tyrosine kinase ZAP-70 and phosphodiesterase IV (PDE-IV). The invention provides medicaments and methods for the treatment of inflammatory dermatological diseases, particularly eczemas, comprising Oxaprozin or a closely related compound or a salt thereof.

  本发明涉及一种治疗皮肤病的新原理，包括抑制炎症级联反应中的几个关键步骤，至少包括抑制一种或多种酶蛋白酪氨酸激酶Syk、蛋白酪氨酸激酶ZAP-70和磷酸二酯酶IV（PDE-IV）。本发明提供了治疗炎症性皮肤病，特别是湿疹的药物和方法，其中包含 Oxaprozin 或一种密切相关的化合物或其盐。
• Dermatological compositions and salts for the treatment of dermatological diseases
  申请人：Weidner Sloth Morten

  公开号：US20060222671A1

  公开（公告）日：2006-10-05

  The invention relates to dermatological compositions of Oxaprozin or a closely related compound suitable adapted for the treatment of a dermatological disease, where at least two of the enzymes selected from protein tyrosine kinase Syk, protein tyrosine kinase ZAP-70 and phosphodiesterase IV play a role in mediating the dermatological disease. The invention also encompasses dermatological compositions for the treatment of pruritus.

  本发明涉及奥沙普秦或密切相关化合物的皮肤病组合物，适用于治疗皮肤病，其中至少两种酶选自蛋白酪氨酸激酶Syk、蛋白酪氨酸激酶ZAP-70和磷酸二酯酶IV，它们在介导皮肤病中发挥作用。本发明还包括用于治疗瘙痒症的皮肤病组合物。