1-methyl-2-(propan-2-yl)-1H-imidazole-4-sulfonyl chloride | 1340300-24-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-methyl-2-(propan-2-yl)-1H-imidazole-4-sulfonyl chloride
• 英文别名: 1-methyl-2-propan-2-ylimidazole-4-sulfonyl chloride
• CAS: 1340300-24-4
• 化学式: C₇H₁₁ClN₂O₂S
• mdl: MFCD19663586
• 分子量: 222.69
• InChiKey: VVBVSGJCTVHRGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  60.3
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• SULFONYLUREAS AND SULFONYLTHIOUREAS AS NLRP3 INHIBITORS
  申请人：Inflazome Limited

  公开号：US20210122716A1

  公开（公告）日：2021-04-29

  The present invention relates to sulfonylureas and sulfonylthioureas comprising a monocyclic imidazolyl group. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP 3 .
• [EN] SULFONYLUREAS AND SULFONYLTHIOUREAS AS NLRP3 INHIBITORS<br/>[FR] SULFONYLURÉES ET SULFONYLTHIOURÉES UTILISÉS EN TANT QU'INHIBITEURS DE NLRP3
  申请人：INFLAZOME LTD

  公开号：WO2019034693A1

  公开（公告）日：2019-02-21

  The present invention relates to sulfonylureas and sulfonylthioureas comprising a monocyclic imidazolyl group. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.