5-Methyl-2-(3-trifluoromethylphenyl)-2H-1,2,3-triazole-4-carboxylic acid | 241797-98-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-Methyl-2-(3-trifluoromethylphenyl)-2H-1,2,3-triazole-4-carboxylic acid
• 英文别名: 5-Methyl-2-(3-(trifluoromethyl)phenyl)-2H-1,2,3-triazole-4-carboxylic acid；5-methyl-2-[3-(trifluoromethyl)phenyl]triazole-4-carboxylic acid
• CAS: 241797-98-8
• 化学式: C₁₁H₈F₃N₃O₂
• 分子量: 271.199
• InChiKey: RZXPQGURVSXIER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  68
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] N-[(SUBSTITUTED FIVE-MEMBERED DI- OR TRIAZA DIUNSATURATED RING)CARBONYL] GUANIDINE DERIVATIVES FOR THE TREATMENT OF ISCHEMIA<br/>[FR] DERIVES DE LA N-[(A CYCLE DI OU TRIAZA DIINSATURE SUBSTITUE) CARBONYLE] GUANIDINE UTILISES POUR LE TRAITEMENT DE L'ISCHEMIE
  申请人：PFIZER PRODUCTS INC.

  公开号：WO1999043663A1

  公开（公告）日：1999-09-02

  (EN) NHE-1 inhibitors, methods of using such NHE-1 inhibitors and pharmaceutical compositions containing such NHE-1 inhibitors. The NHE-1 inhibitors are useful for the reduction of tissue damage resulting from tissue ischemia.(FR) L'invention porte sur des inhibiteurs du NHE-1, sur leurs procédés d'utilisation, et sur des préparations pharmaceutiques les contenant. Lesdits inhibiteurs servent à réduire les dommages tissulaires résultant de l'ischémie des tissus.

  NHE-1抑制剂，使用这种NHE-1抑制剂的方法以及含有这种NHE-1抑制剂的药物组合物。这些NHE-1抑制剂有助于减少组织缺血引起的组织损伤。
• N-[(substituted five-membered di-or triaza diunsaturated ring)carbonyl] guanidine derivatives for the treatment of ischemia
  申请人：Pfizer Inc.

  公开号：US20030149043A1

  公开（公告）日：2003-08-07

  NHE-1 inhibitors, methods of using such NHE-1 inhibitors and pharmaceutical compositions containing such NHE-1 inhibitors. The NHE-1 inhibitors are useful for the reduction of tissue damage resulting from tissue ischemia.

  NHE-1抑制剂，使用这种NHE-1抑制剂的方法以及含有这种NHE-1抑制剂的制药组合物。NHE-1抑制剂对于减少组织缺血引起的组织损伤是有用的。
• N-[(SUBSTITUTED FIVE-MEMBERED DI- OR TRIAZA DIUNSATURATED RING)CARBONYL]GUANIDINE DERIVATIVES FOR THE TREATMENT OF ISCHEMIA
  申请人：Pfizer Products Inc.

  公开号：EP1056729A1

  公开（公告）日：2000-12-06
• Cosmetic composition comprising at least one branched sulphonic polyester and at least one conditioning agent
  申请人：Rollat-Corvol Isabelle

  公开号：US20050002887A1

  公开（公告）日：2005-01-06

  The invention relates to a cosmetic composition for keratin fibers such as the hair, comprising at least one branched sulphonic polyester and at least one conditioning agent chosen from the group comprising non-volatile silicones, cationic or amphoteric polymers and cationic or amphiphilic surfactants. The invention is also directed towards a process for treating keratin fibers such as the hair, in particular a process for fixing and/or holding the hairstyle using the said composition, as well as to the use of this composition in or for the manufacture of a cosmetic hair-styling formulation.
• US6492401B1
  申请人：——

  公开号：US6492401B1

  公开（公告）日：2002-12-10