1H-imidazole-2-carboxylic acid butyl ester | 79711-62-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1H-imidazole-2-carboxylic acid butyl ester
• 英文别名: butyl imidazole-2-carboxylate；butyl 1H-imidazole-2-carboxylate
• CAS: 79711-62-9
• 化学式: C₈H₁₂N₂O₂
• 分子量: 168.195
• InChiKey: YSBMKMFFLVZZTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  55
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1H-imidazole-2-carboxylic acid butyl ester 、 2-溴甲基萘 以6.4 g (71%) of the product were obtained的产率得到Butyl 1-(2-naphthyl)methylimidazole-2-carboxylate
  参考文献：
  名称：

  Novel heterocyclically substituted amides, their preparation and use

  摘要：

  通式I1的酰胺及其互变异构和同分异构形式，可能的对映异构体和顺反异构体形式，以及可能的生理耐受盐，其中变量的含义如描述中所述，它们的制备和用作钙蛋白酶抑制剂。

  公开号：

  US20040097508A1

文献信息

• Heterocyclically substituted amides, their preparation and use
  申请人：BASF Aktiengesellschaft

  公开号：US06630493B1

  公开（公告）日：2003-10-07

  Amides of the general formula I and their tautomeric and isomeric forms, possible enantiomeric and diastereomeric forms, as well as possible physiologically tolerable salts, in which the variables have the meanings stated in the description, their preparation and use as calpain inhibitors.

  一般式I的酰胺及其互变异构和同分异构形式，可能的对映异构体和非对映异构体形式，以及可能的生理耐受盐，其中变量的含义如描述中所述，它们的制备和用作钙蛋白酶抑制剂。
• [EN] SYNTHESIS OF ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS<br/>[FR] SYNTHÈSE D'ANALOGUES D'AMINOGLYCOSIDE ANTIBACTÉRIENS
  申请人：ACHAOGEN INC

  公开号：WO2019079613A1

  公开（公告）日：2019-04-25

  The present disclosure relates to novel methods for preparing antibacterial sisomicin-type aminoglycoside compounds, as well as to related intermediates, and crystal forms thereof, useful in such methods.

  本公开涉及用于制备抗菌的Sisomicin型氨基糖苷化合物的新方法，以及相关的中间体和晶体形式，在这些方法中有用。
• A METHOD FOR PREPARING POLYESTERAMIDES BY ORGANIC CATALYSIS
  申请人：Nanjing Tech University

  公开号：EP3228651A1

  公开（公告）日：2017-10-11

  This invention discloses a method for preparing polyesteramides by organocatalysis. The polyesteramides are prepared by a ring-opening polymerization reaction of comonomer under the action of an activator and an initiator, with ε-caprolactone and ε-caprolactam taken as the comonomer, and an I type carbene carboxylate compound or an L type carbene carboxylate compound taken as catalysts. Compared with the prior art, the method for preparing polyesteramides takes carbene as the catalyst and ε-caprolactone and ε-caprolactam as the reaction monomer, therefore, the total yield can reach 91.2%-97.1%, and degradable polyesteramide copolymers with different melting points (Tm) within 50-200°C can be prepared by adjusting the ratio of raw materials in a formula. At the same time, by the tensile test performed at a room temperature of 15 °C, the humidity of 50% and the speed of 200 mm/min, the hot pressed die sheet, which is 1.00 mm thick and 6.00mm wide, and made of the polyesteramides prepared by the method, has the tensile strength between 10 MPa and 60 MPa, and the Young's modulus between 0.1 GPa and 2 GPa.

  本发明公开了一种通过有机催化制备聚酯酰胺的方法。以ε-己内酯和ε-己内酰胺为共聚单体，以 I 型碳烯羧酸化合物或 L 型碳烯羧酸化合物为催化剂，在活化剂和引发剂的作用下，通过共聚单体的开环聚合反应制备聚酯酰胺。与现有技术相比，该聚酯酰胺的制备方法以碳烯为催化剂，以ε-己内酯和ε-己内酰胺为反应单体，因此总收率可达91.2%-97.1%，并可通过调整配方中原料的比例，制备出熔点（Tm）在50-200℃之间的可降解聚酯酰胺共聚物。同时，在室温 15 ℃、湿度 50%、速度 200 mm/min 的条件下进行拉伸试验，由该方法制备的聚酯酰胺制成的厚 1.00 mm、宽 6.00 mm 的热压模片的拉伸强度在 10 MPa 至 60 MPa 之间，杨氏模量在 0.1 GPa 至 2 GPa 之间。
• Sulfonamides for the treatment of congestive heart failure, their compositions and uses.
  申请人：Cytokinetics, Inc.

  公开号：EP1605752B1

  公开（公告）日：2011-09-14
• PYRIMIDINE COMPOUNDS
  申请人：Taigen Biotechnology

  公开号：EP1890703A2

  公开（公告）日：2008-02-27