benzyl N-[(9S,12S,15S)-9-(hydroxymethyl)-12-(2-methylpropyl)-11,14-dioxo-2-oxa-5,6,7,10,13-pentaazatricyclo[15.2.2.1(4,7)]docosa-1(19),4(22),5,17,20-pentaen-15-yl]carbamate | 1359969-51-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: benzyl N-[(9S,12S,15S)-9-(hydroxymethyl)-12-(2-methylpropyl)-11,14-dioxo-2-oxa-5,6,7,10,13-pentaazatricyclo[15.2.2.1(4,7)]docosa-1(19),4(22),5,17,20-pentaen-15-yl]carbamate
• CAS: 1359969-51-9
• 化学式: C₂₉H₃₆N₆O₆
• 分子量: 564.641
• InChiKey: ZJIBDWBSKPTLOY-HRNNMHKYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.72
• 重原子数：
  41.0
• 可旋转键数：
  6.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  156.7
• 氢给体数：
  4.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  benzyl N-[(9S,12S,15S)-9-(hydroxymethyl)-12-(2-methylpropyl)-11,14-dioxo-2-oxa-5,6,7,10,13-pentaazatricyclo[15.2.2.1(4,7)]docosa-1(19),4(22),5,17,20-pentaen-15-yl]carbamate 在 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 为溶剂， 反应 1.25h， 以65%的产率得到benzyl N-[(9S,12S,15S)-9-formyl-12-(2-methylpropyl)-11,14-dioxo-2-oxa-5,6,7,10,13-pentaazatricyclo[15.2.2.1(4,7)]docosa-1(19),4(22),5,17,20-pentaen-15-yl]carbamate
  参考文献：
  名称：

  New β-Strand Templates Constrained by Huisgen Cycloaddition

  摘要：

  New peptidic templates constrained into a beta-strand geometry by linking acetylene and azide containing P-1 and P-3 residues of a tripeptide by Huisgen cycloaddition are presented. The conformations of the macrocycles are defined by NMR studies and those that best define a beta-strand are shown to be potent inhibitors of the protease calpain. The beta-strand templates presented and defined here are prepared under optimized conditions that should be suitable for targeting a range of proteases and other applications requiring such a geometry.

  DOI：

  10.1021/ol3002199
• 作为产物：
  描述：

  (S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamido)-4-methylpentanoic acid 在 锂硼氢 、 1-羟基苯并三唑 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 25.25h， 生成 benzyl N-[(9S,12S,15S)-9-(hydroxymethyl)-12-(2-methylpropyl)-11,14-dioxo-2-oxa-5,6,7,10,13-pentaazatricyclo[15.2.2.1(4,7)]docosa-1(19),4(22),5,17,20-pentaen-15-yl]carbamate
  参考文献：
  名称：

  New β-Strand Templates Constrained by Huisgen Cycloaddition

  摘要：

  New peptidic templates constrained into a beta-strand geometry by linking acetylene and azide containing P-1 and P-3 residues of a tripeptide by Huisgen cycloaddition are presented. The conformations of the macrocycles are defined by NMR studies and those that best define a beta-strand are shown to be potent inhibitors of the protease calpain. The beta-strand templates presented and defined here are prepared under optimized conditions that should be suitable for targeting a range of proteases and other applications requiring such a geometry.

  DOI：

  10.1021/ol3002199